CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM352
Family Name Prothrombin inhibitor (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide family
No. of Seeds 12 No. of Other Members 10
Family Centroid CFAMM00310659 Functional Category Bioactive
Superfamily Tubulin beta chain Inhibitor DOLASTATIN-10 Superfamily
Class Class 2352

Cousin Family NamesSeedsMembers
Tubulin beta chain Inhibitor DOLASTATIN-10 Family 4 93
Coagulation factor X Inhibitor Phso2-gly-(me-gly)-arg-(2-thiaz... 32 62
Fatty-acid amide hydrolase 1 Inhibitor 7-phenyl-1-(thiazol-2-y... 4 5
Prothrombin inhibitor (3R,6R,8aS)-N-[5-(diaminomethylideneamin... 4 1
Prothrombin inhibitor (6S,8aS)-N-[5-(diaminomethylideneamino)-... 4 4
Prothrombin inhibitor N-[(2S)-3-[(3S)-1-carbamimidoylpiperidin... 4 10
Prolyl endopeptidase inhibitor 4-phenyl-1-[(2S)-2-[(2S)-2-(1,3... 1 0
Coagulation factor XI and Prothrombin inhibitor alpha-ketothia... 5 2
Prothrombin inhibitor (2S)-N-[(4-carbamimidoyl-1,3-thiazol-2-y... 3 2
Cationic trypsin and Prothrombin inhibitor benzyl N-[(2R)-1-[(... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-amin... 1 0
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754DG f... 2 0
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754DR f... 2 2
Coagulation factor X and Prothrombin inhibitor 2-[(3S)-3-benzy... 7 0
Coagulation factor X and Prothrombin inhibitor N-[5-(diaminome... 2 0
Coagulation factor X and Prothrombin inhibitor AGN-PC-0754CL f... 3 0
Trypsin-1 and Prothrombin inhibitor (6S,8aS)-N-[(2S)-5-(diamin... 1 1
Prothrombin inhibitor (3R,6S,8aS)-N-[5-(diaminomethylideneamin... 2 3
Prothrombin and Cationic trypsin inhibitor 2-ketobenzothiazole... 3 0
Caspase-3 and Caspase-1 inhibitor (3S)-5-benzylsulfanyl-4-oxo-... 2 0
Prolyl endopeptidase inhibitor [(2S)-1-[(2S)-1-phenylmethoxypy... 2 0
Coagulation factor X and Prothrombin inhibitor SureCN7377461 f... 4 0
Coagulation factor X and Prothrombin inhibitor 2-[4-(5-chloron... 3 0
Coagulation factor XI and Plasma kallikrein inhibitor alpha-ke... 1 2
Prothrombin and Trypsin-1 inhibitor 2-[(2S)-4-benzyl-2-(naphth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310660 CHEMBL324413 Bioactive (6S,8aS)-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310673 CHEMBL108488 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-(3-naphthalen-2-ylpropanoyl)-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310666 CHEMBL332716 Bioactive (6S,8aS)-N-[(2S)-3-(1-carbamimidoylpiperidin-3-yl)-1-oxo-1-(1,3-thiazol-2-yl)propan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310659 CHEMBL108691 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310672 CHEMBL333154 Bioactive (6S,8aS)-N-[(1S)-1-(1-carbamimidoylpiperidin-4-yl)-2-oxo-2-(1,3-thiazol-2-yl)ethyl]-4-oxo-2-(3-phenylpropanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310657 CHEMBL32182 Bioactive (3S,6S)-6-amino-6-benzyl-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-5-oxo-2,3,7,8-tetrahydro-1H-pyrazolo[1,2-a]pyridazine-3-carboxamide
CFAMM00310670 CHEMBL109883 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-[3-[2-(trifluoromethyl)phenyl]propanoyl]-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310676 CHEMBL431820 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-(3-naphthalen-1-ylpropanoyl)-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310669 CHEMBL107762 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-2-[3-(2-fluorophenyl)propanoyl]-4-oxo-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310662 CHEMBL28922 Bioactive (3S,6S)-6-amino-6-benzyl-N-[(2S)-5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-1,2,3,5,7,8-hexahydropyrazolo[1,2-a]pyridazine-3-carboxamide
CFAMM00310675 CHEMBL321624 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(4-phenylbutanoyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide
CFAMM00310655 CHEMBL321013 Bioactive (6S,8aS)-N-[5-(diaminomethylideneamino)-1-oxo-1-(1,3-thiazol-2-yl)pentan-2-yl]-4-oxo-2-(2-phenylacetyl)-1,3,6,7,8,8a-hexahydropyrrolo[1,2-a]pyrazine-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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