CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM354
Family Name Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC family
No. of Seeds 3 No. of Other Members 8
Family Centroid CFAMM00292192 Functional Category Bioactive
Superfamily Aurora kinase A and Aurora kinase B Binder Superfamily
Class Class 4

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Mizolastine Family 14 603
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-chlo... 11 20
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Aurora kinase A inhibitor 2-[4-[6-chloro-2-[4-(morpholin-4-ylm... 1 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
5-hydroxytryptamine receptor 6 ligand AGN-PC-03P3TZ family 6 88
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Coagulation factor X inhibitor 3-[2-(5-chlorothiophen-2-yl)-3H... 1 10
Coagulation factor X inhibitor SureCN3862475 family 5 2
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Coagulation factor X inhibitor SureCN1678771 family 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M88D fa... 2 1
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Vascular endothelial growth factor receptor 2 and Vascular end... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 5-[5-chloro-... 2 18
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
Transient receptor potential cation channel subfamily V member... 9 13
Epidermal growth factor receptor ligand AGN-PC-00RWHW family 3 4
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 3-(1-... 1 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-0763DE ... 1 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VN4 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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