CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM36
Family Name Integrin beta-3 and Integrin alpha-V inhibitor methyl (3S)-3-(6-methoxypyridin-3-yl)-3-[methyl-[5-(3-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl]amino]propanoate family
No. of Seeds 12 No. of Other Members 13
Family Centroid CFAMM00306206 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-V Binder Superfamily 4
Class Class 851

Cousin Family NamesSeedsMembers
Smoothened homolog Inhibitor LDE225 Family 3 76
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
MK-6096 family 3 69
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Liver carboxylesterase 1 Inhibitor SM-32504 Family 3 28
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03RR5Q f... 3 2
Dihydrofolate reductase inhibitor 10-Oxaaminopterin family 1 2
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(4-ethox... 4 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Integrin beta-3 and Integrin alpha-V inhibitor (3R)-3-quinolin... 6 8
Aurora kinase A inhibitor SureCN761545 family 2 2
Serine/threonine-protein kinase mTOR and RAC-alpha serine/thre... 3 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[6-m... 13 12
Carboxypeptidase B2 and Carboxypeptidase B inhibitor 3-(6-amin... 5 10
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6359092 f... 9 5
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 4 40
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(dime... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor SureCN2059024 f... 6 3
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Integrin beta-3 and Integrin alpha-V inhibitor (3S,7S)-7-hydro... 5 1
Toll-like receptor 7 ligand 4-amino-1-[[6-(2-pyrrolidin-1-ylet... 2 5
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2924568 f... 1 0
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2489170 f... 8 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 42 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Rod cGMP-spec... 24 5
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-(2-hy... 24 0
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(1,3-ben... 8 3
Integrin beta-3 and Integrin alpha-V inhibitor SureCN8335217 f... 2 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN2833591 f... 4 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6223678 f... 14 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN6220269 f... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-03OERH f... 1 0
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-00IW9E f... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 1 0
Growth hormone secretagogue receptor type 1 and Muscarinic ace... 3 9
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-(3-fluor... 10 0
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[3-(2... 4 2
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-(5-chl... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 0
Integrin beta-3 and Integrin alpha-V inhibitor (3S)-3-[[2-[4-(... 3 0
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Acyl-CoA desaturase inhibitor SureCN1182719 family 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 7 6
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Matrilysin and 72 kDa type IV collagenase inhibitor (3S,6R,7S)... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[3,4-di... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306211 CHEMBL9462 Bioactive methyl (3S)-3-[5-(3-amino-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl-methylamino]-3-(6-methoxypyridin-3-yl)propanoate
CFAMM00306204 CHEMBL342305 Bioactive SureCN6810686
CFAMM00306203 CHEMBL9550 Bioactive methyl (3S)-3-[5-[3-(methanesulfonamido)-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl]pentanoyl-methylamino]-3-(6-methoxypyridin-3-yl)propanoate
CFAMM00306216 CHEMBL9208 Bioactive methyl (3S)-3-(6-methoxypyridin-3-yl)-3-[methyl-[5-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl]amino]propanoate
CFAMM00306209 CHEMBL415034 Bioactive methyl (3S)-3-[5-(3-acetamido-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl-methylamino]-3-(6-methoxypyridin-3-yl)propanoate
CFAMM00306202 CHEMBL275555 Bioactive methyl (3S)-3-[5-(3-bromo-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl-methylamino]-3-(6-methoxypyridin-3-yl)propanoate
CFAMM00306215 CHEMBL434124 Bioactive (3S)-3-(6-methoxypyridin-3-yl)-3-[2-oxo-3-[3-oxo-3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]imidazolidin-1-yl]propanoic acid
CFAMM00306201 CHEMBL145085 Bioactive Alpha-V Beta-3 Antagonist
CFAMM00306214 CHEMBL9710 Bioactive methyl (3S)-3-[5-(3-ethenyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl-methylamino]-3-(6-methoxypyridin-3-yl)propanoate
CFAMM00306220 CHEMBL9919 Bioactive methyl (3S)-3-(6-methoxypyridin-3-yl)-3-[methyl-[5-(3-phenyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl]amino]propanoate
CFAMM00306206 CHEMBL10051 Bioactive methyl (3S)-3-(6-methoxypyridin-3-yl)-3-[methyl-[5-(3-methyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)pentanoyl]amino]propanoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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