CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3634
Family Name Disintegrin and metalloproteinase domain-containing protein 17 inhibitor (1S,2S)-2-N-hydroxy-1-N-[4-(quinolin-4-yloxymethyl)phenyl]cyclohexane-1,2-dicarboxamide family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00349370 Functional Category Bioactive
Superfamily Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
Disintegrin and metalloproteinase domain-containing protein 17... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 2 5
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Leukotriene B4 receptor 1 ligand SureCN8987110 family 8 20
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Metabotropic glutamate receptor 2 and Metabotropic glutamate r... 3 3
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 2 13
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Cytochrome P450 11B2, mitochondrial and Cytochrome P450 11B1, ... 9 7
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Disintegrin and metalloproteinase domain-containing protein 17... 44 12
Histone deacetylase 1 and Potassium voltage-gated channel subf... 1 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Prothrombin and Coagulation factor X inhibitor N-[3-[(3-fluoro... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 8 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Prothrombin and Trypsin-1 inhibitor AGN-PC-074I4I family 3 1
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Disintegrin and metalloproteinase domain-containing protein 17... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 9 0
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Histone deacetylase 1 inhibitor 7-[3-fluoro-4-[[3-hydroxy-5-(h... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00349370 CHEMBL135696 Bioactive (1S,2S)-2-N-hydroxy-1-N-[4-(quinolin-4-yloxymethyl)phenyl]cyclohexane-1,2-dicarboxamide
CFAMM00349372 CHEMBL491084 Bioactive (1S,2S)-2-N-hydroxy-1-N-[4-[(2-methylquinolin-4-yl)oxymethyl]phenyl]cyclohexane-1,2-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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