CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3637
Family Name D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C ligand 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-[(2-methoxyphenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00349424 Functional Category Bioactive
Superfamily Beta-lactamase and D(2) dopamine receptor Binder Superfamily 2
Class Class 1560

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Encainide F... 4 248
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-2C adrenergic receptor Ligand ARC239 Family 15 23
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Oxytocin receptor and Vasopressin V1a receptor Ligand L-371257... 8 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Urotensin-2 receptor Ligand JNJ-28318706 Family 4 227
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 3 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Prelamin-A/C and Survival motor neuron protein inhibitor CHEMB... 1 7
C5a anaphylatoxin chemotactic receptor 1 ligand N-[(4-dimethyl... 1 4
Growth hormone secretagogue receptor type 1 ligand (2R)-N-(1-b... 11 4
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 3
Melanin-concentrating hormone receptor 1 ligand 3-[4-[[3-(3-me... 2 10
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-fluoro-5-hydro... 2 0
Delta-type opioid receptor and Kappa-type opioid receptor liga... 5 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 7
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 11 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00349424 CHEMBL135722 Bioactive 8-[4-(4-fluorophenyl)-4-oxobutyl]-3-[(2-methoxyphenyl)methyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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