CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM366
Family Name Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family
No. of Seeds 6 No. of Other Members 13
Family Centroid CFAMM00310850 Functional Category Bioactive
Superfamily Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Superfamily
Class Class 920

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Dihydropterin pyrophosphokinase-dihydropteroate synthase inhib... 5 60
Mast/stem cell growth factor receptor Kit and Vascular endothe... 6 34
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Neuropeptide Y receptor type 5 Ligand CGP71683A Family 5 74
Transient receptor potential cation channel subfamily V member... 15 457
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
JAK Inhibitor Momelotinib Family 33 83
PF-4217903 family 14 65
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Tryptase Inhibitor Babim Family 12 90
Corticotropin-releasing factor receptor 1 Ligand CRA1000 Family 4 39
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Cytochrome P450 11B1, mitochondrial Inhibitor 1-(4-cyanobenzyl... 14 13
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Scytalone dehydratase Inhibitor Isoquinolin-1-yl-(3-phenyl-pro... 4 9
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-(3-cyano-... 2 4
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Aromatase Inhibitor NSC-356781 Family 3 10
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
Oestrogen receptor Ligand 4-benzyl-2,6-diisobutylamino-pyrimid... 5 37
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Potassium voltage-gated channel subfamily H member 2 Ligand AZ... 21 42
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Hepatocyte growth factor receptor Ligand 3-(phenylsulfonyl)-1h... 17 59
Prostaglandin G/H synthase 2 Inhibitor GW-637185X Family 27 48
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Farnesyltransferase beta subunit, putative and Protein farnesy... 12 4
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Acetylcholinesterase Inhibitor N-benzyl-2-morpholinopyrimidin-... 6 16
Adenosine kinase inhibitor abt-702 family 14 1
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... 1 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 4 7
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... 3 7
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Epidermal growth factor receptor ligand AGN-PC-076GVG family 8 1
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Cathepsin K and Potassium voltage-gated channel subfamily H me... 3 1
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Beta-3 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 1
Sorbitol dehydrogenase inhibitor SureCN6335187 family 2 6
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Histamine H4 receptor ligand 2-[[6-iodo-2-(4-methylpiperazin-1... 4 2
Dihydrofolate reductase inhibitor AC1LAKQL family 3 1
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Metabotropic glutamate receptor 2 ligand AGN-PC-09QJ9P family 2 7
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 11 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 5
ALK tyrosine kinase receptor and Insulin receptor ligand N-[(1... 3 6
Fatty-acid amide hydrolase 1 inhibitor 5-[5-(4-chlorophenyl)su... 2 4
Neuropeptide Y receptor type 5 ligand SureCN8898853 family 2 3
Tyrosine-protein kinase JAK2 inhibitor N-tert-butyl-3-[2-[3-fl... 4 14
Aurora kinase A and Cyclin-dependent kinase 1 inhibitor N-[4-[... 12 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 3 0
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Vascular endothelial growth factor receptor 2 ligand urea deri... 3 9
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Vascular endothelial growth factor receptor 2 ligand urea deri... 2 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Mitogen-activated protein kinase 14 inhibitor 6-[5-(2,4-difluo... 9 3
Transient receptor potential cation channel subfamily V member... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and ALK tyrosine kinase receptor ... 5 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Aurora kinase A and Aurora kinase B inhibitor 2-[[5-chloro-2-[... 3 7
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 1 0
Macrophage colony-stimulating factor 1 receptor and Vascular e... 2 3
Aurora kinase B and Vascular endothelial growth factor recepto... 1 2
Mitogen-activated protein kinase kinase kinase 8 and Dual spec... 1 0
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor ligand N-[3-[3-methyl-7-[4-(4... 2 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0760... 4 0
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 3 1
Growth hormone secretagogue receptor type 1 ligand AGN-PC-0074... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
High affinity nerve growth factor receptor ligand N-[3-amino-5... 4 10
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2152398 family 16 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Serine/threonine-protein kinase SMG1 and Serine/threonine-prot... 10 0
Serine/threonine-protein kinase SMG1 and Cyclin-dependent kina... 3 1
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 3 4
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Scavenger receptor class B member 1 ligand 9-[3-(4,6-diethylpy... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... 5 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Serine/threonine-protein kinase ATR and Serine/threonine-prote... 8 10
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Nicotinamide phosphoribosyltransferase and Cytochrome P450 2C9... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor AG... 3 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-(3-cyanophenyl)-... 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Epidermal growth factor receptor ligand Pyrroloquinazoline der... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Cyclin-dependent kinase 2 inhibitor Imidazo[1,2-a]pyridine der... 4 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Serine/threonine-protein kinase B-raf inhibitor imidazole-base... 2 0
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Mitogen-activated protein kinase 8 inhibitor N-[4-[4-[2-(cyclo... 1 0
Focal adhesion kinase 1 and Protein-tyrosine kinase 2-beta inh... 1 1
Transient receptor potential cation channel subfamily V member... 3 2
Ribosomal protein S6 kinase beta-1 and Aurora kinase B inhibit... 1 5
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Mast/stem cell growth factor receptor Kit and Tyrosine-protein... 4 1
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 1 0
LIM domain kinase 2 inhibitor (2S)-N-cyano-N'-[3-(2-hydroxyeth... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NS1A family 7 0
Tyrosine-protein kinase ZAP-70 inhibitor AGN-PC-07CO7Z family 1 0
Histamine H4 receptor ligand 2-[[6-chloro-2-(4-methylpiperazin... 7 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Vascular endothelial growth factor receptor 2 and Cyclin-depen... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310850 CHEMBL1078689 Bioactive AGN-PC-07ZB89
CFAMM00310865 CHEMBL1078889 Bioactive AGN-PC-07ZB9F

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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