CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3671
Family Name Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methyl-2-(1-oxo-2-phenylpyrrolo[3,4-b]quinolin-3-ylidene)acetamide family
No. of Seeds 2 No. of Other Members 13
Family Centroid CFAMM00349683 Functional Category Bioactive
Superfamily Histone deacetylase 6 and Histone deacetylase 1 Binder Superfamily
Class Class 1555

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
Glycogen phosphorylase, muscle form Inhibitor PSN357 Family 3 253
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Receptor-type tyrosine-protein kinase FLT3 Inhibitor SU5614 Fa... 4 36
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
D(4) dopamine receptor Ligand SPI-376 Family 7 84
Setipiprant family 5 118
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-chlorophenyl)-5-... 2 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 93
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Peroxisome proliferator-activated receptor gamma Ligand 2-chlo... 5 19
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 5 22
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Amine oxidase [flavin-containing] A Inhibitor 6-chloro-n-(2-mo... 5 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Substance-P receptor ligand AGN-PC-01ZIXQ family 13 42
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Huntingtin and Glycogen synthase kinase-3 beta inhibitor SB 21... 2 4
5-hydroxytryptamine receptor 2A and Sodium-dependent serotonin... 1 10
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Cannabinoid receptor 1 ligand AGN-PC-04YSUM family 7 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
Nicotinamide phosphoribosyltransferase inhibitor 4-[(7-chloro-... 6 4
Coagulation factor X and Prothrombin inhibitor SureCN763988 fa... 31 86
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Cellular tumor antigen p53 and Ferritin light chain inhibitor ... 1 2
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 36
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor 2-... 18 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
Cannabinoid receptor 1 ligand 5-cyano-1-[(3,5-dichlorophenyl)m... 2 0
Substance-P receptor and Neuromedin-K receptor ligand SureCN88... 4 14
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6R... 2 2
Renin inhibitor [2-[(3-fluoro-2-methylphenyl)methyl]-6-methyl-... 2 1
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 7 12
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 2-... 3 0
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 3 6
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
Translocator protein inhibitor N-(4-chlorophenyl)-N-methyl-2-(... 2 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Lysosomal Pro-X carboxypeptidase inhibitor [(3S,4R)-1-tert-but... 20 13
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Substance-P receptor ligand SureCN7796965 family 9 1
Histamine H1 receptor and Alpha-1B adrenergic receptor ligand ... 8 1
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Neuromedin-K receptor and Potassium voltage-gated channel subf... 13 2
Coagulation factor X and Prothrombin inhibitor SureCN5819494 f... 5 8
Dual specificity protein kinase CLK4 and Mitogen-activated pro... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 8 6
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Motilin receptor ligand SureCN2768052 family 3 0
Seprase and Prolyl endopeptidase inhibitor 7-chloro-N-[2-[(2S)... 3 3
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Acetylcholinesterase inhibitor N-[6-[4-[(6-chloro-1,2,3,4-tetr... 9 0
C-C chemokine receptor type 5 ligand 6-chloro-N-[(3R)-3-[4-[(5... 16 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor 3-... 17 0
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 2 0
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Neuromedin-K receptor ligand SureCN3894466 family 1 0
Cannabinoid receptor 1 ligand AGN-PC-07NHJ5 family 9 1
KiSS-1 receptor ligand SureCN5132924 family 2 4
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN4998361 family 1 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 1 1
Translocator protein inhibitor N,N-dibutyl-2-(7-chloro-2-pheny... 3 1
Nociceptin receptor and Mu-type opioid receptor ligand (1R,5R)... 4 17
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
P2X purinoceptor 7 inhibitor 2-chloro-N-[(1-hydroxy-3,3-dimeth... 1 8
Poly [ADP-ribose] polymerase 1 inhibitor SureCN3553433 family 22 0
Cannabinoid receptor 1 ligand [6-bromo-2-methyl-1-(2-morpholin... 3 0
Glycogen phosphorylase, liver form inhibitor 2-[(1R,2R)-2-[(5-... 3 2
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Tyrosine-protein kinase inhibitor (4-chloro-1H-indol-2-yl)-[(3... 1 0
Acetylcholinesterase inhibitor (9R)-11-amino-6,6,9-trimethyl-9... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00349683 CHEMBL260827 Bioactive (2E)-N-(4-chlorophenyl)-N-methyl-2-(1-oxo-2-phenylpyrrolo[3,4-b]quinolin-3-ylidene)acetamide
CFAMM00349692 CHEMBL135869 Bioactive (2E)-N-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-1-oxopyrrolo[3,4-b]quinolin-3-ylidene]-N-methylacetamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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