CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3684
Family Name Glucosylceramidase and Alpha-galactosidase A inhibitor AC1NNEG1 family
No. of Seeds 4 No. of Other Members 5
Family Centroid CFAMM00349831 Functional Category Bioactive
Superfamily Melanin-concentrating hormone receptor 1 and Beta-secretase 1 Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor VX-702 Family 3 49
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Serine/threonine-protein kinase mTOR Inhibitor AZD2014 Family 2 41
GDC-0349 family 44 77
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 37 10
JAK Inhibitor Momelotinib Family 33 83
XL-888 family 16 85
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 32
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Histamine H3 receptor Ligand 2-(4-isopropyl-piperazin-1-yl)-qu... 17 29
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 19 103
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Amine oxidase [flavin-containing] A Inhibitor 3-benzyl-n-(2-mo... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 25 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Serine/threonine-protein kinase D1 inhibitor SureCN1424142 family 13 8
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
5-hydroxytryptamine receptor 1A ligand AGN-PC-03ZB72 family 10 8
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 19
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 3 3
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Serine/threonine-protein kinase mTOR inhibitor SureCN2707225 f... 29 4
Serine/threonine-protein kinase mTOR inhibitor AGN-PC-088SNX f... 1 0
Beta-secretase 1 inhibitor 3-[2-amino-6-(2-methylphenyl)quinol... 5 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 18 5
5-hydroxytryptamine receptor 3A ligand 3-methyl-N-[7-[[3-methy... 2 0
Substance-P receptor ligand Netupitant family 5 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 0
Microsomal triglyceride transfer protein large subunit inhibit... 13 0
Melanin-concentrating hormone receptor 1 ligand SureCN4261878 ... 4 7
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 6-... 1 0
Serine/threonine-protein kinase mTOR inhibitor 2-[4-[4-[(3S)-3... 3 0
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 7 7
C-X-C chemokine receptor type 3 ligand 1-[3-[[(1R,5S)-3-[[7-(t... 3 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 2
P2X purinoceptor 7 inhibitor 2-(1-adamantyl)-N-[2-(3-hydroxypr... 2 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN8... 3 0
Cannabinoid receptor 2 ligand AGN-PC-07CRHA family 4 8
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Dihydrofolate reductase inhibitor N-(2,4-diamino-5-methylquina... 2 0
Acetyl-CoA carboxylase 2 and Acetyl-Coenzyme A carboxylase 2 i... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00349831 CHEMBL403714 Bioactive AC1NNEG1
CFAMM00349829 CHEMBL259853 Bioactive MLS000044220
CFAMM00349836 CHEMBL260291 Bioactive Aminoquinoline compound, 17
CFAMM00349835 CHEMBL259854 Bioactive Aminoquinoline compound, 16

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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