CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM37
Family Name Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ligand (3S)-3-phenyl-1-[[(6R)-6,7,8,9-tetrahydrobenzo[g][1,3]benzodioxol-6-yl]methyl]pyrrolidine family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00074669 Functional Category Bioactive
Superfamily Cytochrome P450 3A4 and Tumor necrosis factor Binder Superfamily
Class Class 719

Cousin Family NamesSeedsMembers
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 5 209
Noradrenergic re-uptake and Serotonin re-uptake inhibitor bicy... 6 375
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 61 433
u-type opioid receptor ligand opiate analog Buprenorphine Family 78 234
Histamine H1 receptor Ligand Doxepin Family 8 89
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
D(1B) dopamine receptor Ligand Apomorphine Family 30 271
Neuronal acetylcholine receptor subunit alpha-2 Ligand Metocur... 18 169
Muscarinic acetylcholine receptor M3 Ligand Tolterodine Family 8 171
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Oestrogen receptor Ligand Lasofoxifene Family 19 152
Endothelin-1 receptor Ligand Atrasentan Family 127 336
D(3) dopamine receptor Ligand U-99194A Family 7 33
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Squalene synthase Inhibitor (z)-3-[2-(9h-fluoren-2-yloxy)ethyl... 12 92
D(2) dopamine receptor and D(1A) dopamine receptor Ligand A-70... 16 27
Arachidonate 5-lipoxygenase Inhibitor Bw A360C Family 12 8
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Peptide deformylase, mitochondrial Inhibitor Tylophorinidine F... 7 1
Tumor necrosis factor Inhibitor Y-39041 Family 9 51
Histamine H3 receptor Ligand A-331440 Family 6 7
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Histamine H3 receptor Ligand (r)-1-(2-methoxyphenethyl)-2-meth... 10 27
Intercellular adhesion molecule 1 Inhibitor Dehydropipernonali... 5 36
5-hydroxytryptamine receptor 2A Ligand 3-methoxy-9-aminomethyl... 7 14
Sodium-dependent noradrenaline transporter Inhibitor WAY-25680... 4 6
5-hydroxytryptamine receptor 2A and D(1A) dopamine receptor Li... 8 33
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Cytochrome P450 3A4 Inhibitor 1,2-diacetoxylycorine Family 4 19
D(1A) dopamine receptor Ligand SCH-12679 Family 1 0
Tubulin beta chain Inhibitor Colchinol Family 3 109
D(2) dopamine receptor and Sodium-dependent dopamine transport... 6 10
D(2) dopamine receptor and D(1A) dopamine receptor Ligand 3-ch... 2 0
Sodium-dependent dopamine transporter Inhibitor Secocularidine... 3 9
5-hydroxytryptamine receptor 1A ligand SureCN7035190 family 10 17
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 2 1
Sodium-dependent serotonin transporter and Transporter inhibit... 1 0
D(1A) dopamine receptor and D(3) dopamine receptor ligand N,N-... 3 1
D(3) dopamine receptor ligand S 14297 family 1 2
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
DNA-(apurinic or apyrimidinic site) lyase and Menin inhibitor ... 1 6
Transient receptor potential cation channel subfamily V member... 14 7
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Sigma non-opioid intracellular receptor 1 ligand BAS 04057753 ... 5 8
Histamine H3 receptor and Sodium-dependent serotonin transport... 15 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 28
Melanin-concentrating hormone receptor 1 ligand 6-methoxy-4-[[... 2 15
7-dehydrocholesterol reductase inhibitor 2-[2-(4-chlorophenyl)... 2 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 6 1
Sodium-dependent serotonin transporter and Histamine H3 recept... 7 0
Putative Bioactive 5-hexyl-2-[4-[(4-methylpiperazin-1-yl)methy... 2 0
Alpha-2A adrenergic receptor and Alpha-2C adrenergic receptor ... 2 26
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 0
Mu-type opioid receptor ligand N-[2-[(2-amino-2-oxoethyl)-[2-(... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (E)-... 1 0
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00PO2W family 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00306221 CHEMBL9844 Bioactive 5-[[2-(1,3-benzodioxol-5-yl)ethyl-methylamino]methyl]-5,6,7,8-tetrahydronaphthalen-1-ol

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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