CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM371
Family Name Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 inhibitor AGN-PC-04YWF6 family
No. of Seeds 1 No. of Other Members 11
Family Centroid CFAMM00310890 Functional Category Bioactive
Superfamily Aurora kinase A and Aurora kinase B Binder Superfamily 2
Class Class 2020

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 5 12
Smoothened homolog Inhibitor LDE225 Family 3 76
MK-6096 family 3 69
JAK Inhibitor Momelotinib Family 33 83
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 3
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Muscarinic acetylcholine receptor M2 and Muscarinic receptor 3... 4 3
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN12658... 3 19
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Calcium/calmodulin-dependent protein kinase kinase 2 and Focal... 3 17
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
Mitogen-activated protein kinase 14 inhibitor 3-fluoro-N-[4-me... 2 5
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
Glycogen synthase kinase-3 beta inhibitor CHEMBL1940990 family 3 3
Histamine H3 receptor ligand N-[[2-[2-[(2R)-2-methylpyrrolidin... 4 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[4-(4-pip... 1 11
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 3 3
Cathepsin K and Cathepsin L1 inhibitor 2-Cyano-pyrimidine, 17a... 5 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 8
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Angiopoietin-1 receptor and Vascular endothelial growth factor... 4 6
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
G-protein coupled bile acid receptor 1 ligand 2-ethyl-6-[3-[4-... 4 6
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Aurora kinase B and Aurora kinase A inhibitor 2-fluoro-6-metho... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Focal adhesion kinase 1 inhibitor 2-[[2-(2-methoxy-4-morpholin... 2 1
Angiopoietin-1 receptor and Vascular endothelial growth factor... 5 0
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 1
Vasopressin V1a receptor and Vasopressin V2 receptor ligand AG... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[(2S)-azet... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 5
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cathepsin S and Cathepsin L1 inhibitor AGN-PC-077QOL family 1 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Transient receptor potential cation channel subfamily V member... 2 0
Neuropeptide Y receptor type 5 ligand SureCN2658856 family 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00310890 CHEMBL1078364 Bioactive AGN-PC-04YWF6

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27759 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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