CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3718
Family Name Coagulation factor X and Trypsin-1 inhibitor 2-(5-carbamimidoyl-1H-indol-3-yl)-N-[2-fluoro-4-(2-sulfamoylphenyl)phenyl]acetamide family
No. of Seeds 5 No. of Other Members 2
Family Centroid CFAMM00225057 Functional Category Bioactive
Superfamily Coagulation factor X and cAMP-specific 3',5'-cyclic phosphodiesterase 4B Binder Superfamily
Class Class 8

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Lethal factor Inhibitor GM6001 Family 50 435
Class II cytokine receptor Ligand IL-10 Family 7 45
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-075TBZ family 2 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Coagulation factor X and Trypsin-1 inhibitor 4-(3-carbamimidoy... 2 1
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Mitogen-activated protein kinase 9 and MAP kinase-activated pr... 1 0
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 0
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Coagulation factor X inhibitor (Z)-3-(3-carbamimidoylphenyl)-2... 2 2
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Suppressor of tumorigenicity 14 protein and Prothrombin inhibi... 1 3
Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... 4 0
Coagulation factor X inhibitor (E)-2-fluoro-3-[3-(N'-methylcar... 1 0
Coagulation factor X and Prothrombin inhibitor SureCN7690879 f... 3 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27619 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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