CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3729
Family Name Thyroid hormone receptor beta and Ferritin light chain ligand CHEMBL1553013 family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00350156 Functional Category Bioactive
Superfamily Thrombopoietin receptor and Follicle-stimulating hormone receptor Binder Superfamily
Class Class 170

Cousin Family NamesSeedsMembers
Abelson tyrosine-protein kinase 2 inhibitor thiazole derivativ... 19 50
Mast/stem cell growth factor receptor Kit and Abelson tyrosine... 6 537
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Cathepsin B and Cathepsin K Inhibitor L-006235-1 Family 19 75
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Type-2 angiotensin II receptor Ligand L-158282 Family 24 58
Adenosine receptor A1 Ligand 4-nitro-n-(4-phenyl-thiazol-2-yl)... 2 38
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 3 5
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Insulin receptor and Tyrosine-protein kinase Lck ligand AGN-PC... 1 1
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Metabotropic glutamate receptor 1 ligand N-cyclohexyl-7-[[2-me... 2 0
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Cyclin-dependent kinase 5 and G1/S-specific cyclin-E1 inhibito... 1 1
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Cell division cycle 7-related protein kinase and Protein DBF4 ... 2 1
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 8
cAMP-dependent protein kinase catalytic subunit beta and cAMP-... 2 9
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 5 5
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
D(3) dopamine receptor ligand N-[4-[2-[[(6S)-2-amino-4,5,6,7-t... 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Metabotropic glutamate receptor 5 ligand 5-methyl-N-(4-methyl-... 1 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 8 1
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Serine/threonine-protein kinase Chk1 inhibitor 2-(1,3-dihydroi... 2 5
Serine/threonine-protein kinase Chk1 inhibitor 2-indazol-1-yl-... 4 5
Orexin receptor type 2 and Orexin receptor type 1 ligand 6-ami... 3 1
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-[1-(3-chloro-4-fluorophenyl)i... 2 0
MAP kinase-activated protein kinase 2 inhibitor 2-[(4,4-dimeth... 11 11
Thrombopoietin receptor ligand N-[4-[2-fluoro-3-(trifluorometh... 2 14
Glycylpeptide N-tetradecanoyltransferase inhibitor N-[2-(2-met... 5 8
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MSE family 18 2
Tyrosine-protein kinase Lck inhibitor AGN-PC-074MPV family 4 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03HL8Q family 4 0
Coagulation factor X inhibitor SureCN8290907 family 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 5 0
Receptor-type tyrosine-protein kinase FLT3 ligand SureCN74238 ... 6 0
Protein-cysteine N-palmitoyltransferase porcupine inhibitor N-... 3 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 2 0
Histone deacetylase 1 inhibitor SureCN1066177 family 1 1
Glucagon receptor and Gastric inhibitory polypeptide receptor ... 2 13


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00350157 CHEMBL2148217 Bioactive N-[4-[2-[[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-propylamino]ethyl]cyclohexyl]-4-imidazol-1-ylbenzamide
CFAMM00350154 CHEMBL584508 Bioactive GNF-Pf-3947
CFAMM00350161 CHEMBL2148219 Bioactive N-[4-[2-[[(6S)-2-amino-4,5,6,7-tetrahydro-1,3-benzothiazol-6-yl]-propylamino]ethyl]cyclohexyl]-3-imidazol-1-ylbenzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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