CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3735
Family Name Substance-P receptor ligand AGN-PC-075NSQ family
No. of Seeds 9 No. of Other Members 3
Family Centroid CFAMM00350213 Functional Category Bioactive
Superfamily ABC transporter inhibitor Benzquinamide, amine transporter inhibitor Tetrabenazine Superfamily
Class Class 92

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Multidrug resistance protein Inhibitor Benzquinamide Family 1 41
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Endothelin-1 receptor Ligand Atrasentan Family 127 336
Myeloperoxidase Inhibitor AZD5904 Family 1 2
Substance-P receptor Ligand Ezlopitant Family 10 207
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 16
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Neutrophil elastase Inhibitor N,n-bis(cyanomethyl)-3,4-dimetho... 3 30
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 55 36
Neutrophil elastase inhibitor (2S)-N-[(3S)-6-benzamido-5,5-dif... 6 10
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 2 9
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL14038... 1 9
Prelamin-A/C and Retinal dehydrogenase 1 inhibitor CHEMBL15810... 1 1
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 13
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1589265 family 1 0
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Angiotensin-converting enzyme and Angiotensin-converting enzym... 3 13
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Mu-type opioid receptor ligand AGN-PC-075GAW family 2 1
Melanin-concentrating hormone receptor 1 and Potassium voltage... 3 6
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Sodium-dependent noradrenaline transporter and Sodium-dependen... 6 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Cannabinoid receptor 1 ligand AGN-PC-03RV6L family 10 3
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Substance-P receptor ligand SureCN9054944 family 1 0
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 2 20
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
Survival motor neuron protein and Muscleblind-like protein 1 i... 1 10
Protease inhibitor (2S)-N-[4-(1,3-benzodioxol-5-ylmethylamino)... 1 2
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0
Prostaglandin D2 receptor ligand (E)-7-[(1S,3S,4R,5R)-4-(1,3-b... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00350210 CHEMBL140134 Bioactive AGN-PC-075NRA
CFAMM00350203 CHEMBL139015 Bioactive AGN-PC-075NP8
CFAMM00350209 CHEMBL138853 Bioactive AGN-PC-075NSZ
CFAMM00350202 CHEMBL139176 Bioactive AGN-PC-075NWS
CFAMM00350208 CHEMBL136305 Bioactive AGN-PC-03ITO9
CFAMM00350207 CHEMBL139967 Bioactive AGN-PC-075NUC
CFAMM00350213 CHEMBL139226 Bioactive AGN-PC-075NSQ
CFAMM00350205 CHEMBL137609 Bioactive AGN-PC-075NRO
CFAMM00350204 CHEMBL138890 Bioactive AGN-PC-075NT4

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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