CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3745
Family Name Survival motor neuron protein and DNA-(apurinic or apyrimidinic site) lyase inhibitor CHEMBL1363891 family
No. of Seeds 1 No. of Other Members 5
Family Centroid CFAMM00288262 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Prelamin-A/C Binder Superfamily 10
Class Class 2070

Cousin Family NamesSeedsMembers
Acetylcholinesterase Inhibitor Edrophonium Family 7 40
Acetylcholinesterase Inhibitor Neostigmine Family 4 76
Beta-1 adrenergic receptor Ligand Practolol Family 2 82
D(2) dopamine receptor Ligand Aplindore Fumarate Family 2 30
D(2) dopamine receptor Ligand Pardoprunox Family 4 81
Tumor necrosis factor Inhibitor Tgaac-94 Family 6 107
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
5-hydroxytryptamine receptor 1A Ligand NAN-190 Family 14 28
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 18 12
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Alpha-1A adrenergic receptor Ligand RWJ-68141 Family 5 4
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Histone deacetylase 1 Inhibitor 7-(4-(dimethylamino)phenoxy)-n... 2 1
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor Propan-2-one O-4-(hexyl... 12 4
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Fatty-acid amide hydrolase 1 Inhibitor Phenmedipham Family 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 9 28
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 21 13
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 9
Liver carboxylesterase 1 Inhibitor SCH-48375 Family 2 28
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 18
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 4
Acetylcholinesterase inhibitor AGN-PC-075N8G family 2 9
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Survival motor neuron protein and ATP-dependent DNA helicase Q... 1 4
Neuropeptide S receptor and Survival motor neuron protein liga... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 4
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 2 4
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 1 0
Dipeptidyl peptidase 4 inhibitor (2S)-1-[(2S,4S)-4-(4-methoxya... 1 26
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
Cathepsin K inhibitor (1R,2R)-N-(cyanomethyl)-2-[4-(3-methoxyp... 2 1
Angiotensin-converting enzyme inhibitor AGN-PC-076HUS family 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 0
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-[2-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00350294 CHEMBL139497 Bioactive SureCN10324092

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24328 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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