CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3806
Family Name Mitogen-activated protein kinase 1 and M17 leucyl aminopeptidase inhibitor CHEMBL1367693 family
No. of Seeds 1 No. of Other Members 21
Family Centroid CFAMM00350794 Functional Category Bioactive with Natural Product
Superfamily M17 leucyl aminopeptidase and Nuclear receptor ROR-gamma Binder Superfamily
Class Class 106

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
Histone deacetylase 1 Inhibitor Vorinostat Family 26 138
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Bifunctional epoxide hydrolase 2 Inhibitor 1-cyclohexyl-3-phen... 5 65
Tyrosine-protein phosphatase non-receptor type 1 Ligand [[4-(a... 1 7
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Protein kinase C eta type and Protein kinase C delta type Inhi... 9 12
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 1 16
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(2S)-1... 6 6
Pol polyprotein inhibitor Lysine Sulfonamide 11o family 2 6
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Dipeptidyl peptidase 4 inhibitor SureCN1499864 family 4 7
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Stromelysin-1 inhibitor 6-(4'-FLUORO-BIPHENYL-4-YL)-4-(3-METHY... 3 0
Kappa-type opioid receptor ligand 4-[3-[(1S)-1-[methyl-[2-[4-(... 1 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-1-... 3 3
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
Integrin beta-3 and Integrin alpha-V inhibitor AGN-PC-037CNR f... 5 8
Granzyme B and Caspase-3 inhibitor CHEMBL304368 family 2 1
Caspase-8 and Caspase-3 inhibitor (3S)-3-[[(2S)-4-methyl-2-[[2... 3 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
Glutamate carboxypeptidase 2 inhibitor (2S)-2-[[(1S)-1-carboxy... 3 4
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Peptide deformylase inhibitor N-[(2R,4S)-2-butyl-5-methyl-3-ox... 2 0
Aminopeptidase N inhibitor (2S)-2-[(2-chlorophenyl)carbamoylam... 1 1
Integrin beta-1 and Integrin alpha-5 inhibitor (Z)-2-[1-[(4-am... 1 1
Integrin beta-3 and Integrin alpha-V inhibitor SureCN5878455 f... 4 0


External ID

Functional Category

Molecule Name

CFAMM00350784 CHEMBL2408792 Bioactive 2-methyl-2-[[(2S)-4-methyl-2-[[4-(trifluoromethyl)phenyl]carbamoylamino]pentanoyl]amino]propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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