CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3849
Family Name Gastrin/cholecystokinin type B receptor and Cholecystokinin receptor type A ligand AGN-PC-00OPNO family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00351136 Functional Category Bioactive
Superfamily Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole Analogue Superfamily
Class Class 930

Cousin Family NamesSeedsMembers
Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
5-hydroxytryptamine receptor Ligand Ramosetron Family 10 219
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Histamine H1 receptor Ligand Mizolastine Family 14 603
Transient receptor potential cation channel subfamily V member... 15 158
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor BMS214662... 11 65
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
Translocator protein Inhibitor Emapunil Family 7 89
Growth hormone receptor Ligand EP-51216 Family 34 390
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
NS5A protein Inhibitor Bms 790052 Family 5 9
BIBT986 family 7 96
Amg 423 family 7 47
SB989 family 17 91
Plinabulin family 1 0
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Lethal factor Inhibitor GM6001 Family 50 435
Adenosine receptor A1 and Adenosine receptor A2a Ligand 8-phen... 12 213
Tryptase Inhibitor Babim Family 12 90
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
5-hydroxytryptamine receptor 2B Ligand Sb 206553 Family 14 21
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 45
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... 5 2
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Histamine H4 receptor ligand SureCN602132 family 1 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 1 2
Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... 1 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
Coagulation factor X and Trypsin-1 inhibitor 1-(3-carbamimidoy... 4 1
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Coagulation factor X and Coagulation factor IX inhibitor 5-ami... 9 4
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Serine/threonine-protein kinase mTOR inhibitor 5-(2-amino-3H-b... 3 1
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Growth hormone secretagogue receptor type 1 ligand SureCN36660... 4 14
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 1 4
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Cdc2-related kinase inhibitor N-[6-(3,5-dimethylphenyl)-1-meth... 1 0
Somatostatin receptor type 3 and Somatostatin receptor type 4 ... 5 1
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206058 family 5 0
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 2
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand (2R)-... 12 16
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Calcitonin gene-related peptide type 1 receptor ligand N-[2-(7... 16 0
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... 2 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 0
Metabotropic glutamate receptor 2 ligand 8-(2,5-difluorophenyl... 6 2
Prothrombin inhibitor N-(2-aminoethyl)-2-[5-[[3-(benzylsulfony... 17 5
Proteinase-activated receptor 1 and Prothrombin ligand (2S)-N-... 3 23
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chlor... 1 0
Gastrin/cholecystokinin type B receptor ligand 2-[6-[[2-[5-cyc... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
B1 bradykinin receptor ligand AGN-PC-077LWO family 2 0
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Calcitonin gene-related peptide type 1 receptor ligand SureCN3... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00351136 CHEMBL352217 Bioactive AGN-PC-00OPNO

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26816 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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