CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3886
Family Name C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-[ethyl(pyrimidin-2-yl)amino]piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid family
No. of Seeds 9 No. of Other Members 4
Family Centroid CFAMM00351374 Functional Category Bioactive
Superfamily Renin and C-C chemokine receptor type 5 Binder Superfamily
Class Class 1170

Cousin Family NamesSeedsMembers
Integrin alpha-4 Inhibitor CDP323 Family 8 17
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 44
C-C chemokine receptor type 5 ligand AC1LA25C family 3 6
Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5
A disintegrin and metalloproteinase with thrombospondin motifs... 1 3
C-C chemokine receptor type 5 ligand SureCN13543564 family 10 3
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
C-C chemokine receptor type 5 ligand (2R)-3-cyclobutyl-2-[(3S,... 2 0


External ID

Functional Category

Molecule Name

CFAMM00351367 CHEMBL428104 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[propyl(pyrimidin-2-yl)amino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351365 CHEMBL275998 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[(4-methoxypyrimidin-2-yl)-propylamino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351364 CHEMBL344641 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[propyl-[5-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351374 CHEMBL343366 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-[ethyl(pyrimidin-2-yl)amino]piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid
CFAMM00351371 CHEMBL343745 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[propyl-[4-(trifluoromethyl)pyrimidin-2-yl]amino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351363 CHEMBL344261 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[(5-fluoropyrimidin-2-yl)-propylamino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351369 CHEMBL335562 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[propyl(pyrimidin-5-yl)amino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid
CFAMM00351362 CHEMBL137327 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-[[4-[cyclopropylmethyl(pyrimidin-2-yl)amino]piperidin-1-yl]methyl]-4-(3-fluorophenyl)pyrrolidin-1-yl]propanoic acid
CFAMM00351372 CHEMBL342842 Bioactive (2R)-3-cyclobutyl-2-[(3S,4S)-3-(3-fluorophenyl)-4-[[4-[propyl(pyrimidin-4-yl)amino]piperidin-1-yl]methyl]pyrrolidin-1-yl]propanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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