CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3897
Family Name Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL1374262 family
No. of Seeds 1 No. of Other Members 36
Family Centroid CFAMM00351505 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protein kinase Src Binder Superfamily
Class Class 1340

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
HIV protease Inhibitor Saquinavir Family 64 428
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Histidine decarboxylase Inhibitor Bf-derm1 Family 12 95
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Neuromedin-K receptor Ligand SB222200 Family 17 235
Cholecystokinin receptor type A Ligand Tarazepide Family 6 323
Poly [ADP-ribose] polymerase 1 Inhibitor AG-14699 Family 13 179
Reverse transcriptase Inhibitor IDX899 Family 2 118
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Glutamate receptor AMPA subtype Ligand CX-516 Family 9 24
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Setipiprant family 5 118
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
CP-18770 family 6 27
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
XL-888 family 16 85
Cyclin-dependent kinase 5 Inhibitor 9-nitropaullone Family 2 13
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 1-(9h-... 4 25
Fibroblast growth factor receptor 2 Ligand Interferon Alfa (if... 14 162
Cannabinoid receptor 2 Ligand JWH-167 Family 25 168
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Potassium voltage-gated channel subfamily H member 2 Ligand E-... 1 4
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cannabinoid receptor 2 Ligand JWH-204 Family 6 10
Cannabinoid receptor 2 Ligand JWH-249 Family 7 13
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Branched-chain-amino-acid aminotransferase, cytosolic Inhibito... 1 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 24 50
Poly [ADP-ribose] polymerase 1 Inhibitor 2-ethylquinoline-8-ca... 3 4
Transient receptor potential cation channel subfamily V member... 6 23
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 37 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-2... 8 1
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Microsomal triglyceride transfer protein large subunit Inhibit... 5 9
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Mineralocorticoid receptor and Androgen receptor Ligand WAY-25... 10 26
14-alpha sterol demethylase Inhibitor CP-320626 Family 13 76
Poly [ADP-ribose] polymerase 1 Inhibitor 3-ethenylquinoline-8-... 8 4
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 3-phen... 10 27
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Glutamate receptor 1 Ligand Piriqualone Family 8 67
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 27
Endothelin B receptor Ligand IRL-2500 Family 34 87
Amine oxidase [flavin-containing] A Inhibitor N-benzyl-1h-pyrr... 12 46
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 1-(3-(2-methylquinoli... 2 12
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Acetylcholinesterase and Cholinesterase Inhibitor 7-oxo-7h-dib... 2 3
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Histone deacetylase Inhibitor ST-5732 Family 8 6
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Pol polyprotein inhibitor N-[(2S)-1-[[(2S,3R,4S,5S)-3,4-dihydr... 2 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 1 13
Progesterone receptor and Androgen receptor ligand AGN-PC-04V9... 2 2
Substance-P receptor ligand N-[(1S,2R)-2-[[(1R)-1-[methyl-(2-p... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Sodium-dependent serotonin transporter and Sodium-dependent do... 10 2
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 0
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor AGN-PC... 4 21
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
C-C chemokine receptor type 5 and C-C motif chemokine 5 ligand... 1 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 13 1
Cellular tumor antigen p53 inhibitor CHEMBL1418224 family 1 62
Melanin-concentrating hormone receptor 1 ligand AGN-PC-09M6QF ... 3 0
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
Translocator protein inhibitor (2E)-N-(4-chlorophenyl)-N-methy... 2 13
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 1 0
Thyroid hormone receptor beta and Microtubule-associated prote... 1 8
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Prelamin-A/C and Pyruvate kinase PKM inhibitor CHEMBL1481187 f... 1 7
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 1
Acetylcholinesterase inhibitor CHEMBL1651131 family 6 9
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Translocator protein inhibitor AGN-PC-08WI0V family 1 0
Dipeptidyl peptidase 4 inhibitor AGN-PC-09QKOM family 5 8
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
ALK tyrosine kinase receptor and Insulin receptor ligand 9-eth... 9 8
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 3 2
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... 4 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 1 0
Renin inhibitor (3R,4S)-N-cyclopropyl-N-[[2-(3-methoxypropyl)q... 2 0
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL186461 family 2 4
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... 5 11
Poly [ADP-ribose] polymerase 1 inhibitor CHEMBL1935258 family 7 2
Translocator protein inhibitor N,N-diethyl-11-(2-fluoroethyl)-... 14 9
Cannabinoid receptor 1 ligand (2-cyclopentyl-5-prop-2-enyl-3,4... 3 8
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 14 1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 5
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 3 5
Histone deacetylase 6 and Histone deacetylase 1 inhibitor 4-[(... 2 9
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Cannabinoid receptor 1 ligand N-[2-(cyclopropylamino)-2-oxoeth... 5 5
Hematopoietic prostaglandin D synthase inhibitor 4-(3-methylis... 1 7
High affinity nerve growth factor receptor and BDNF/NT-3 growt... 4 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 5 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B and cAMP-speci... 2 3
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 6 6
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Prostaglandin D2 receptor 2 ligand 2-[(3R)-3-(3,3-diphenylprop... 1 0
Prostaglandin D2 receptor 2 and Cytochrome P450 2C19 ligand 2-... 6 13
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
RAC-beta serine/threonine-protein kinase and 3-phosphoinositid... 11 4
Coagulation factor X inhibitor 3-chloro-N-[(1S,2S)-2-[[4-(2-ox... 22 3
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Fatty-acid amide hydrolase 1 inhibitor 1-[3-[4-(6-phenylhexyl)... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 7 9
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Motilin receptor ligand SureCN2768052 family 3 0
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Prostaglandin D2 receptor 2 ligand 2-[3-[(E)-2-cyano-3-(N-meth... 9 9
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Leucine-rich repeat serine/threonine-protein kinase 2 and Plat... 1 0
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3-fluo... 6 4
3-oxo-5-alpha-steroid 4-dehydrogenase 2 and 3-oxo-5-alpha-ster... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 6-(b... 5 5
Hepatocyte growth factor receptor and Protein-tyrosine kinase ... 2 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 3
Substance-P receptor ligand AGN-PC-004REJ family 3 0
Platelet-activating factor receptor ligand (1-ethylindol-3-yl)... 17 13
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 7 18
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 1 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Coagulation factor X and Trypsin-1 inhibitor SureCN6166035 family 1 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 0
Coagulation factor X and Prothrombin inhibitor N,1-bis[(3-carb... 1 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
Carbonic anhydrase 2 and Carbonic anhydrase inhibitor 3-(3-chl... 6 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
Translocator protein inhibitor 2-(7-Chloro-5-methyl-4-oxo-3-ph... 1 0
Histamine H3 receptor ligand SureCN3542210 family 1 0
5-hydroxytryptamine receptor 7 ligand AGN-PC-00PFK0 family 1 0
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 4 4
Heat shock protein HSP 90-alpha inhibitor CHEMBL1760611 family 19 25
Methionine aminopeptidase 1 inhibitor ethyl 4-[4-(2-pyridin-2-... 2 3
Endothelin-converting enzyme 1 inhibitor 5-(3,3-dimethylbutano... 1 1
Peroxisome proliferator-activated receptor gamma ligand N-(5-c... 1 3
Voltage-dependent N-type calcium channel subunit alpha-1B liga... 2 0
Ketohexokinase inhibitor 3-carbamimidoyl-N-(3-ethyl-1-phenylin... 1 0
Potassium voltage-gated channel subfamily A member 5 ligand 3-... 1 0
Histone deacetylase 1 and HD2 type histone deacetylase HDA106 ... 1 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00351499 CHEMBL2441464 Bioactive N-[3-[3-(piperidine-1-carbonyl)carbazol-9-yl]propyl]methanesulfonamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45918 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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