CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM3967
Family Name Survival motor neuron protein inhibitor CHEMBL1379159 family
No. of Seeds 1 No. of Other Members 10
Family Centroid CFAMM00352021 Functional Category Bioactive
Superfamily Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-imidazol-1-yl-phenoxy)-propyl]-pyridine Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Serine/threonine-protein kinase Chk2 Inhibitor 5-nitro-2-(4-ph... 6 3
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Oestrogen receptor and Estrogen receptor beta Ligand 4-(2-phen... 2 9
Melanin-concentrating hormone receptor 1 Ligand ADS-103214 Family 3 4
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 10 46
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 7 13
Cathepsin S and Cathepsin K inhibitor SureCN1629664 family 10 11
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 10 54
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 9 19
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
Translocator protein inhibitor SureCN6906757 family 3 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Neuropeptide Y receptor type 1 ligand 2-[(4-chlorophenoxy)meth... 5 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 2 15
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 7 2
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 1
Casein kinase I isoform delta and Casein kinase I isoform gamm... 1 2
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 1
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Mu-type opioid receptor and Nitric oxide synthase, brain ligan... 3 0
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 1-... 8 6
Glutamate receptor ionotropic, NMDA 2B ligand 2-[[4-(4-chlorop... 4 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Tyrosine-protein kinase Lck inhibitor 3-[[2-(benzimidazol-1-yl... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
D(2) dopamine receptor ligand SureCN11039666 family 1 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
C-C chemokine receptor type 5 ligand SureCN13543570 family 2 0
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
Metabotropic glutamate receptor 2 ligand 2-[[(1R,5S)-6-[(2,5-d... 2 3
5-hydroxytryptamine receptor 1A ligand AGN-PC-04UH85 family 2 3
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Cannabinoid receptor 2 ligand SureCN14457828 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Oxytocin receptor ligand AGN-PC-07C71T family 3 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 1 1
Fatty-acid amide hydrolase 1 inhibitor bisarylimidazole deriva... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN8919280 f... 23 18
Beta-2 adrenergic receptor and Beta-3 adrenergic receptor liga... 4 6
Coagulation factor X inhibitor AGN-PC-07C2VY family 1 0
Fatty-acid amide hydrolase 1 and Cytosolic phospholipase A2 in... 1 0
DNA-(apurinic or apyrimidinic site) lyase and Survival motor n... 1 2
Metabotropic glutamate receptor 5 ligand AGN-PC-09QKEE family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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