CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM399
Family Name Protein kinase C theta type and Protein kinase C delta type inhibitor SureCN2935541 family
No. of Seeds 7 No. of Other Members 17
Family Centroid CFAMM00170625 Functional Category Bioactive
Superfamily Protein kinase C theta type and Protein kinase C delta type Binder Superfamily
Class Class 1666

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
Acetylcholinesterase Inhibitor Tacrine Family 12 515
Histamine H1 receptor Ligand Triprolidine Family 19 316
Thromboxane A2 receptor Ligand Ramatroban Family 13 49
5-hydroxytryptamine receptor 6 Ligand SB-742457 Family 9 66
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
E7820 family 9 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Protein kinase C theta type Inhibitor 4-(3h-indol-4-ylamino)-5... 2 2
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Glucocorticoid receptor ligand N-[(3S)-3-[1-(4-fluorophenyl)in... 11 24
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Cannabinoid receptor 2 ligand AGN-PC-09M5PW family 12 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 5 10
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Glucocorticoid receptor ligand 2,4,6-trimethyl-N-[(2S)-1-[[6-m... 16 1
Progesterone receptor and Mineralocorticoid receptor ligand AG... 6 1
Mineralocorticoid receptor and Glucocorticoid receptor ligand ... 5 0
Glucocorticoid receptor ligand SureCN5650626 family 17 25
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Hepatocyte growth factor receptor ligand AGN-PC-08XYH3 family 1 0
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
CGMP-dependent protein kinase inhibitor AGN-PC-075XII family 25 7
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[3-[(4-fluo... 3 2
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
Glutamate receptor ionotropic, NMDA 2B ligand N-[3-[2-(4-benzy... 2 0
Leucine-rich repeat serine/threonine-protein kinase 2 inhibito... 1 4
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Serine/threonine-protein kinase Chk1 inhibitor 5-[7-(2-morphol... 2 2
CGMP-dependent protein kinase inhibitor methyl 2-[[4-[5-(4-flu... 6 1
Sodium-dependent serotonin transporter and D(2) dopamine recep... 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
5-hydroxytryptamine receptor 6 ligand 3,4-dichloro-N-[3-[[(2R)... 5 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
CGMP-dependent protein kinase inhibitor 2-[[4-[5-(4-fluorophen... 1 0
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Prostaglandin G/H synthase 2 inhibitor SureCN6345015 family 6 1
CGMP-dependent protein kinase inhibitor AGN-PC-078XQ0 family 1 1
5-hydroxytryptamine receptor 6 ligand 2-[[(1Z)-1-[5-(benzenesu... 1 0
5-hydroxytryptamine receptor 6 ligand 4-bromo-N-[3-[[(2S)-1-me... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311094 CHEMBL1079567 Bioactive SureCN2937443

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27398 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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