CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4024
Family Name Prolyl endopeptidase inhibitor (2R)-1-[(2S)-1-[3-[(2R)-2-acetylpyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile family
No. of Seeds 15 No. of Other Members 9
Family Centroid CFAMM00352408 Functional Category Bioactive
Superfamily Prolyl endopeptidase Binder Superfamily
Class Class 2656

Cousin Family NamesSeedsMembers
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
DNA Binder Procarbazine Family 8 358
Bavisant family 9 65
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Neutrophil elastase Inhibitor FK-706 Family 8 85
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Arachidonate 5-lipoxygenase Inhibitor N-hydroxy-n-methyl-benza... 3 9
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 5 3
Prolyl endopeptidase inhibitor 2-hydroxy-1-[(2S)-1-[(2S)-1-[3-... 8 0
Dipeptidyl peptidase 4 inhibitor SureCN2709139 family 5 7
Histamine H3 receptor and Potassium voltage-gated channel subf... 9 0
Dipeptidyl peptidase 4 inhibitor 4-cyano-N-[4-[(2S)-2-cyanopyr... 1 1
Melanin-concentrating hormone receptor 1 and Cytochrome P450 2... 3 4
Muscarinic acetylcholine receptor M3 and Muscarinic receptor 3... 3 0
Prolyl endopeptidase and Seprase inhibitor [(2R)-1-[2-[benzoyl... 2 0
Prolyl endopeptidase inhibitor 2-{3-[(2s)-4,4-Difluoro-2-(Pyrr... 2 2
C-C chemokine receptor type 5 ligand N-benzyl-N-[(3R)-1-[(1S,5... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352411 CHEMBL364335 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-(cyclohexanecarbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352417 CHEMBL187830 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-acetylpyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352423 CHEMBL425001 Bioactive (2S)-1-[(2S)-1-[4-(pyrrolidine-1-carbonyl)benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352422 CHEMBL140461 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352428 CHEMBL191572 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-(cyclopentanecarbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352415 CHEMBL364989 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-benzoylpyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352408 CHEMBL138635 Bioactive (2R)-1-[(2S)-1-[3-[(2R)-2-acetylpyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352421 CHEMBL188379 Bioactive (2S)-1-[(2S)-1-[3-[(2S)-2-(2-methylpropanoyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352414 CHEMBL191061 Bioactive (2S)-1-[(2S)-1-[3-(pyrrolidine-1-carbonyl)benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352427 CHEMBL140969 Bioactive (2S)-1-[(2S)-1-[3-[2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352407 CHEMBL188501 Bioactive (2S)-1-[(2S)-1-[3-(azepane-1-carbonyl)benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352406 CHEMBL341691 Bioactive (2R)-1-[(2S)-1-[3-[(2R)-2-(cyclohexanecarbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352412 CHEMBL138334 Bioactive (2R)-1-[(2S)-1-[3-[(2R)-2-(2-methylpropanoyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352425 CHEMBL138361 Bioactive (2R)-1-[(2S)-1-[3-[(2R)-2-(cyclopentanecarbonyl)pyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
CFAMM00352418 CHEMBL408666 Bioactive (2R)-1-[(2S)-1-[3-[(2R)-2-benzoylpyrrolidine-1-carbonyl]benzoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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