CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4033
Family Name Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075OEX family
No. of Seeds 6 No. of Other Members 8
Family Centroid CFAMM00351966 Functional Category Bioactive
Superfamily Stromelysin-1 and Neutrophil collagenase Binder Superfamily 2
Class Class 3081

Cousin Family NamesSeedsMembers
72 kDa type IV collagenase Inhibitor SC-74020 Family 1 21
C-C chemokine receptor type 8 Ligand N-(4-phenylsulfamoyl-naph... 4 62
Interstitial collagenase and Neutrophil collagenase inhibitor ... 3 9
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 6 7
Neutrophil collagenase and Stromelysin-1 inhibitor 2-[7-amino-... 3 23
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-074A... 6 4
Apolipoprotein B-100 and Microsomal triglyceride transfer prot... 3 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 10 1
Bifunctional epoxide hydrolase 2 inhibitor 1-(2,4-dimethylphen... 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-[[4... 7 11
Collagenase 3 and Neutrophil collagenase inhibitor (2R)-2-[ben... 2 12
Microbial collagenase inhibitor AGN-PC-00F1J7 family 4 2
Orexin receptor type 2 ligand SureCN1039013 family 1 0
Prothrombin and Cationic trypsin inhibitor (2R)-N-[[(3S)-1-car... 1 2
Calpain-1 catalytic subunit inhibitor 2-methyl-6-morpholin-4-y... 1 2


External ID

Functional Category

Molecule Name

CFAMM00352482 CHEMBL141560 Bioactive AGN-PC-075OHX
CFAMM00352473 CHEMBL58932 Bioactive (3R)-2-[4-[4-(dimethylamino)phenyl]phenyl]sulfonyl-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352476 CHEMBL294426 Bioactive tert-butyl N-[(3R)-2-[4-(4-fluorophenyl)phenyl]sulfonyl-3-(hydroxycarbamoyl)-3,4-dihydro-1H-isoquinolin-7-yl]carbamate
CFAMM00352485 CHEMBL56893 Bioactive (3R)-7-amino-2-[4-(4-fluorophenyl)phenyl]sulfonyl-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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