CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4043
Family Name Gonadotropin-releasing hormone receptor ligand 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid family
No. of Seeds 28 No. of Other Members 19
Family Centroid CFAMM00352541 Functional Category Bioactive
Superfamily Gonadotropin-releasing hormone receptor Binder Superfamily 2
Class Class 3306

Cousin Family NamesSeedsMembers
Gonadotropin-releasing hormone receptor and Gonadotropin-relea... 2 2
Gonadotropin-releasing hormone receptor ligand 7-chloro-3-(3,5... 1 2
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Gonadotropin-releasing hormone receptor ligand 7-chloro-2-oxo-... 11 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-073E7... 2 4
Gonadotropin-releasing hormone receptor ligand 1-[7-chloro-3-(... 7 1
Gonadotropin-releasing hormone receptor ligand SureCN8149183 f... 5 0
Gonadotropin-releasing hormone receptor ligand 4-[2-[(2S)-azet... 1 0
Gonadotropin-releasing hormone receptor ligand 7-chloro-3-(3,5... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352546 CHEMBL336884 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-N-(6-methylpyrimidin-4-yl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352572 CHEMBL300295 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-4-[2-[(2S,6R)-6-methylpiperidin-2-yl]ethoxy]-2-oxo-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352559 CHEMBL138747 Bioactive 7-chloro-N-(6-chloropyrimidin-4-yl)-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352552 CHEMBL184819 Bioactive 7-chloro-2-oxo-4-[2-(oxolan-2-yl)ethoxy]-N-pyrimidin-4-yl-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352578 CHEMBL360429 Bioactive 7-chloro-2-oxo-N-pyrimidin-4-yl-4-[2-[(2S,6R)-6-(trifluoromethyl)piperidin-2-yl]ethoxy]-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352558 CHEMBL48879 Bioactive 7-chloro-4-[2-[(2S,6S)-6-methylpiperidin-2-yl]ethoxy]-2-oxo-N-pyrimidin-4-yl-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352571 CHEMBL48674 Bioactive 7-chloro-3-(2,3-dihydro-1H-inden-5-yl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352564 CHEMBL298937 Bioactive 7-chloro-2-oxo-N-pyrimidin-4-yl-4-[2-[(2S)-6-(trifluoromethyl)piperidin-2-yl]ethoxy]-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352577 CHEMBL48192 Bioactive SureCN1535403
CFAMM00352544 CHEMBL138866 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-N-(2-methylpyrimidin-4-yl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352557 CHEMBL71561 Bioactive 4-[2-[(2S)-azetidin-2-yl]ethoxy]-7-chloro-2-oxo-N-pyrimidin-2-yl-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352570 CHEMBL295948 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-4-[2-[(2S,6S)-6-methylpiperidin-2-yl]ethoxy]-2-oxo-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352543 CHEMBL45784 Bioactive 7-chloro-3-(3,4-dichlorophenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352569 CHEMBL362544 Bioactive 7-chloro-2-oxo-N-pyrimidin-4-yl-4-[2-[(2S)-pyrrolidin-2-yl]ethoxy]-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352582 CHEMBL48249 Bioactive 7-chloro-3-(5-chlorothiophen-2-yl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352549 CHEMBL139292 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-N-(2-methoxypyrimidin-4-yl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352555 CHEMBL45883 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-N-pyrazin-2-yl-1H-quinoline-6-carboxamide
CFAMM00352568 CHEMBL49230 Bioactive 7-chloro-3-(3,4-dimethylphenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352581 CHEMBL52278 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352548 CHEMBL341809 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352541 CHEMBL2111956 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352554 CHEMBL138464 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-N-pyrazin-2-yl-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352580 CHEMBL51841 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-4-[2-[(2S)-6-ethylpiperidin-2-yl]ethoxy]-2-oxo-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352567 CHEMBL365366 Bioactive 7-chloro-4-[2-[(2S,6R)-1-methyl-6-(trifluoromethyl)piperidin-2-yl]ethoxy]-2-oxo-N-pyrimidin-4-yl-3-(3,4,5-trimethylphenyl)-1H-quinoline-6-carboxamide
CFAMM00352573 CHEMBL45501 Bioactive 2-[7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-1H-quinolin-6-yl]-N-pyrimidin-4-ylacetamide
CFAMM00352540 CHEMBL46177 Bioactive 7-chloro-3-(3,5-dichlorophenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide
CFAMM00352553 CHEMBL138999 Bioactive 7-chloro-3-(3,5-dimethylphenyl)-2-oxo-4-(2-piperidin-2-ylethoxy)-N-pyridin-2-yl-1H-quinoline-6-carboxamide;2,2,2-trifluoroacetic acid
CFAMM00352566 CHEMBL48165 Bioactive 7-chloro-3-(4-iodo-3-methylphenyl)-2-oxo-4-[2-[(2S)-piperidin-2-yl]ethoxy]-N-pyrimidin-4-yl-1H-quinoline-6-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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