CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4063
Family Name Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-aminopropanoyl]amino]-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide family
No. of Seeds 10 No. of Other Members 9
Family Centroid CFAMM00349111 Functional Category Bioactive
Superfamily Neutrophil collagenase and Stromelysin-1 Binder Superfamily
Class Class 3978

Cousin Family NamesSeedsMembers
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Disintegrin and metalloproteinase domain-containing protein 17... 25 33
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 2 55
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 2-[benz... 9 9
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 16
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 4-acety... 9 4
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Pol polyprotein inhibitor AC1LAPRV family 13 7
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 7 12
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 12
Pol polyprotein inhibitor AC1LAGJO family 6 1
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075O... 14 27
Pol polyprotein inhibitor AC1LA9K7 family 7 23
Collagenase 3 and 72 kDa type IV collagenase inhibitor (5R)-N-... 7 0
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Neutrophil collagenase and Stromelysin-1 inhibitor tert-butyl ... 2 0
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R)-1-... 25 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4Z)... 17 0
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Pol polyprotein inhibitor SureCN4637317 family 19 6
Bone morphogenetic protein 1 inhibitor 3-[[4-(benzylcarbamoyla... 1 9
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 13 3
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Neutrophil elastase inhibitor 2-[3-[(4-methoxyphenyl)sulfonyla... 1 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 6 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor N-hydro... 3 1
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 2 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 3-N-hyd... 1 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzo... 6 7
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 2
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[[2-(... 2 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(3S)-2... 2 2
Coagulation factor X inhibitor N-[1-[2-fluoro-4-(2-methylsulfo... 2 2
Elongation of very long chain fatty acids protein 6 inhibitor ... 2 7
Bone morphogenetic protein 1 inhibitor (2R)-5-[(2-chlorophenyl... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352704 CHEMBL138613 Bioactive tert-butyl N-[(2S)-1-[[3-(hydroxycarbamoyl)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-7-yl]amino]-1-oxopropan-2-yl]carbamate
CFAMM00352697 CHEMBL60579 Bioactive tert-butyl N-[(3R)-3-(hydroxycarbamoyl)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-7-yl]carbamate
CFAMM00352696 CHEMBL56250 Bioactive (3R)-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-7-nitro-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352702 CHEMBL292671 Bioactive (3S)-7-[[(2S)-2-aminopropanoyl]amino]-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352695 CHEMBL139542 Bioactive AGN-PC-075ODD
CFAMM00352708 CHEMBL299936 Bioactive (3R)-7-amino-N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352701 CHEMBL56137 Bioactive tert-butyl N-[(2S)-1-[[(3S)-3-(hydroxycarbamoyl)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-7-yl]amino]-1-oxopropan-2-yl]carbamate
CFAMM00352698 CHEMBL141359 Bioactive AGN-PC-03SZ9T

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27518 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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