CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4065
Family Name Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-075ODY family
No. of Seeds 14 No. of Other Members 27
Family Centroid CFAMM00306239 Functional Category Bioactive
Superfamily Disintegrin and metalloproteinase domain-containing protein 17 and Interstitial collagenase Binder Superfamily
Class Class 3248

Cousin Family NamesSeedsMembers
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Endothelin-1 receptor Ligand Atrasentan Family 127 336
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 15 129
Disintegrin and metalloproteinase domain-containing protein 17... 82 411
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Disintegrin and metalloproteinase domain-containing protein 17... 25 33
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 7
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 6 16
Matrix metalloproteinase-9 and Collagenase 3 inhibitor 4-benzy... 10 32
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Muscarinic acetylcholine receptor M2 ligand [4-[(3R)-4-[(1S)-1... 3 13
Disintegrin and metalloproteinase domain-containing protein 17... 10 39
Collagenase 3 and Interstitial collagenase inhibitor N-hydroxy... 8 4
Collagenase 3 and Interstitial collagenase inhibitor AGN-PC-01... 10 1
Cathepsin K inhibitor SureCN6578603 family 1 3
Collagenase 3 and Interstitial collagenase inhibitor (1R,5S)-3... 2 1
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor AC1L4BQ... 3 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 4-acety... 9 4
Collagenase 3 and Matrix metalloproteinase-9 inhibitor (4R)-N-... 13 4
Pol polyprotein inhibitor benzyl (2S)-2-[[[(2S)-3-[cyclopentyl... 2 6
Collagenase 3 and Stromelysin-1 inhibitor 1-N-benzyl-3-N-hydro... 7 15
Matrix metalloproteinase-9 and Collagenase 3 inhibitor N-hydro... 2 1
Matrix metalloproteinase-9 and Collagenase 3 inhibitor AGN-PC-... 7 12
Renin inhibitor (1R,5S)-N-cyclopropyl-N-[(3-methoxy-2-methylph... 4 4
Lethal(3)malignant brain tumor-like protein 1 inhibitor CHEMBL... 1 5
Neutrophil collagenase and Stromelysin-1 inhibitor 7-[[(2S)-2-... 10 9
Collagenase 3 and 72 kDa type IV collagenase inhibitor (5R)-N-... 7 0
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-073U... 4 6
Neutrophil collagenase inhibitor (3R)-2-[4-[4-(dimethylamino)p... 2 4
Neutrophil collagenase and Stromelysin-1 inhibitor AGN-PC-044L... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R)-1-... 25 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4S)... 7 1
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
72 kDa type IV collagenase and Collagenase 3 inhibitor (2R,4S)... 3 0
Matrix metalloproteinase-15 and Matrix metalloproteinase-16 in... 1 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R,4Z)... 17 0
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Disintegrin and metalloproteinase domain-containing protein 17... 4 2
Muscarinic acetylcholine receptor M2 ligand (2R)-4-cyclohexyl-... 12 0
Macrophage metalloelastase and 72 kDa type IV collagenase inhi... 7 4
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor AGN-PC-... 3 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 19 11
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Disintegrin and metalloproteinase domain-containing protein 17... 6 12
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor 1-ethyl... 11 5
Disintegrin and metalloproteinase domain-containing protein 17... 5 2
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 4 0
Growth hormone secretagogue receptor type 1 ligand 2-benzylsul... 2 0
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 25 5
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 3 0
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 4 6
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-2-... 2 0
Collagenase 3 and Neutrophil collagenase inhibitor (3R)-1-hydr... 1 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 7 1
Pol polyprotein inhibitor MDL 74538 family 11 1
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 3 0
Carbonic anhydrase 7 and Carbonic anhydrase 14 inhibitor 4-(6-... 7 8
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor 6-hydr... 1 5
Disintegrin and metalloproteinase domain-containing protein 17... 12 1
Disintegrin and metalloproteinase domain-containing protein 17... 9 3
Disintegrin and metalloproteinase domain-containing protein 17... 3 3
Bone morphogenetic protein 1 inhibitor benzyl N-[(4R)-4-[1,3-b... 6 25
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-[(4-b... 3 1
Macrophage metalloelastase inhibitor 2-(2,5-dichlorophenyl)sul... 1 1
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 0
72 kDa type IV collagenase and Disintegrin and metalloproteina... 5 1
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 12 3
Calpain-1 catalytic subunit inhibitor 2-ethyl-1,1-dioxo-N-[(2S... 4 30
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 13 3
Bone morphogenetic protein 1 inhibitor (2R)-2-[1,3-benzodioxol... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Pol polyprotein inhibitor N-[2-Hydroxy-2-(8-Isopropyl-6,9-Diox... 7 6
Disintegrin and metalloproteinase domain-containing protein 17... 13 1
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Neutrophil elastase inhibitor 2-[3-[(4-methoxyphenyl)sulfonyla... 1 0
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzy... 6 2
Collagenase 3 and Matrix metalloproteinase-9 inhibitor N-hydro... 3 1
Neutrophil collagenase and Interstitial collagenase inhibitor ... 3 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 0
Collagenase 3 and Disintegrin and metalloproteinase domain-con... 2 0
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 1
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-acety... 6 7
Collagenase 3 and Matrix metalloproteinase-9 inhibitor 1-benzo... 6 7
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 3 2
72 kDa type IV collagenase and Collagenase 3 inhibitor 2-[[2-(... 2 0
72 kDa type IV collagenase and Collagenase 3 inhibitor AGN-PC-... 4 0
72 kDa type IV collagenase and Interstitial collagenase inhibi... 2 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[(3S)-2... 2 2
Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[2-(3-methoxyp... 1 0
Bone morphogenetic protein 1 inhibitor (2R)-2-[(4-bromophenyl)... 1 4
Bone morphogenetic protein 1 inhibitor N-hydroxy-3-[[4-[(Z)-N'... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352739 CHEMBL301675 Bioactive ethyl [(3R)-3-(hydroxycarbamoyl)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-7-yl] carbonate
CFAMM00352732 CHEMBL57461 Bioactive (3R)-2-(4-butoxyphenyl)sulfonyl-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352737 CHEMBL138643 Bioactive AGN-PC-044LPD
CFAMM00352723 CHEMBL293359 Bioactive (3R)-N,7-dihydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352729 CHEMBL138814 Bioactive AGN-PC-03SZ9S
CFAMM00352741 CHEMBL56093 Bioactive (3R)-N-hydroxy-2-(4-phenoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352747 CHEMBL58829 Bioactive (3R)-2-[4-[(4-fluorophenyl)methoxy]phenyl]sulfonyl-N-hydroxy-3,4-dihydro-1H-isoquinoline-3-carboxamide
CFAMM00352740 CHEMBL417926 Bioactive [(3R)-3-(hydroxycarbamoyl)-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinolin-7-yl] 4-methoxybenzenesulfonate
CFAMM00352733 CHEMBL341604 Bioactive AGN-PC-044LPS

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27526 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543