CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4066
Family Name Lethal(3)malignant brain tumor-like protein 1 and Lysine-specific demethylase 4E inhibitor CHEMBL1386435 family
No. of Seeds 1 No. of Other Members 6
Family Centroid CFAMM00352751 Functional Category Bioactive with Natural Product
Superfamily Survival motor neuron protein and Huntingtin Binder Superfamily
Class Class 2912

Cousin Family NamesSeedsMembers
Alpha-2C adrenergic receptor Ligand MK-912 Family 1 3
Histamine H3 receptor Ligand A-317920 Family 9 240
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor Lig... 3 89
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
cAMP-specific 3',5'-cyclic phosphodiesterase 4A Inhibitor 4-(2... 4 31
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 8 66
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 14
Histamine H3 receptor Ligand A-349821 Family 49 228
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Estradiol 17-beta-dehydrogenase 1 Inhibitor N(furan-2-ylmethyl... 2 1
Caspase-3 Inhibitor 2-(4-methoxy-benzyl)isoquinoline-1,3,4-tri... 2 2
Cytochrome P450 2D6 Inhibitor (5-phenylfuran-2-yl)methanamine ... 1 4
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 33
Melatonin receptor type 1A and Melatonin receptor type 1B Liga... 33 98
Macrophage migration inhibitory factor Inhibitor Benzofuran-2-... 5 67
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 5 11
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 1 4
Fatty-acid amide hydrolase 1 Inhibitor Furan-2-ylmethylcarbami... 1 105
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 24 73
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 62
Substance-K receptor ligand 5-chloro-N-[1-[[(2S)-5-[4-(oxan-4-... 2 4
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 8 36
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 1 4
Sodium-dependent dopamine transporter and Sigma non-opioid int... 7 5
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 20 9
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 2 2
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
Prelamin-A/C and Beta-lactamase inhibitor CHEMBL1424193 family 1 0
Survival motor neuron protein and Retinal dehydrogenase 1 inhi... 2 9
Mu-type opioid receptor ligand SureCN9379472 family 1 1
Histamine H3 receptor ligand SureCN2786002 family 8 3
Prostaglandin E2 receptor EP4 subtype ligand SureCN5653729 family 3 2
Histamine H3 receptor ligand SureCN2785131 family 7 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 7 18
Mu-type opioid receptor ligand AGN-PC-075GAC family 16 8
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase and Sigma no... 2 4
Lysosomal Pro-X carboxypeptidase inhibitor 1'-(1-benzofuran-2-... 1 0
Histamine H3 receptor ligand SureCN5218144 family 4 6
Alpha-2C adrenergic receptor and Alpha-2A adrenergic receptor ... 4 13
Protein farnesyltransferase subunit beta and Protein farnesylt... 2 0
Mu-type opioid receptor ligand AGN-PC-00NCMO family 3 1
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 1
Protein kinase C theta type and Protein kinase C epsilon type ... 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Gonadotropin-releasing hormone receptor ligand N-[[4-[(diamino... 6 4
Histone deacetylase 6 and Histone deacetylase 1 inhibitor (E)-... 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27047 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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