CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4089
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-benzodioxol-5-yl)-2-(pyridine-3-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00352888 Functional Category Bioactive
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase and Prelamin-A/C Binder Superfamily
Class Class 3477

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... 2 30
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 21 11
Leukotriene B4 receptor 1 ligand SureCN8987047 family 4 3
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family 1 30
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 7 4
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Butyrylcholinesterase and Acetylcholinesterase inhibitor AGN-P... 9 24
Peroxisome proliferator-activated receptor gamma ligand AGN-PC... 5 12
Sodium-dependent serotonin transporter inhibitor (4S)-4-[4-[(2... 1 3
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2A lig... 1 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand [5-(o... 4 4
Prostaglandin D2 receptor and Prostaglandin E2 receptor EP2 su... 2 0
NS5B protein inhibitor AC1O5AET family 3 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 1
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Melanin-concentrating hormone receptor 1 and Potassium voltage... 1 2
Acetylcholinesterase and Butyrylcholinesterase inhibitor (E)-3... 4 5
Cholinesterase and Acetylcholinesterase inhibitor tacrine deri... 10 0
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
Cholinesterase and Acetylcholinesterase inhibitor 6-[2-methoxy... 12 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Mast/stem cell growth factor receptor Kit and Serine/threonine... 11 29
Endothelin-1 receptor and Endothelin B receptor ligand SureCN7... 3 7
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 3 3
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-077PI... 4 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
72 kDa type IV collagenase and Aminopeptidase N inhibitor ly52... 1 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 12
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
DNA topoisomerase 1 inhibitor AC1LAHQQ family 5 14
Indoles Metabolite 4-[N-(p-Coumaroyl)serotonin-4''-yl]-N-ferul... 3 0
Putative NP ZINC12880788 Family 12 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352888 CHEMBL138799 Bioactive 3-(1,3-benzodioxol-5-yl)-2-(pyridine-3-carbonyl)-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00352885 CHEMBL344366 Bioactive 3-(1,3-benzodioxol-5-yl)-2-benzoyl-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

38798 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543