CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4102
Family Name Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluoroanilino)-7-(4-morpholin-4-ylbutyl)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide family
No. of Seeds 8 No. of Other Members 4
Family Centroid CFAMM00352981 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Epidermal growth factor receptor Binder Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Prostaglandin G/H synthase 2 Inhibitor Rpr 200765a Family 9 125
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
JAK Inhibitor Momelotinib Family 33 83
Bacterial outer membrane Inhibitor HKI-9924129 Family 19 85
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Peptide deformylase, mitochondrial Inhibitor 5-chloryl-2,4,6-q... 2 6
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Epidermal growth factor receptor Ligand N*4*-(3-bromo-phenyl)-... 7 11
Epidermal growth factor receptor Ligand Benzo[g]quinazolin-4-y... 5 3
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
5-hydroxytryptamine receptor 1A and D(1A) dopamine receptor li... 2 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Epidermal growth factor receptor ligand pyrido[4,3-d]pyrimidin... 11 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Ephrin type-B receptor 4 and Vascular endothelial growth facto... 1 4
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 3 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Casein kinase I isoform delta and Casein kinase I isoform gamm... 1 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor ligand (2R,3R)-3-[[4-(3-bromo... 3 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 7 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Coagulation factor X inhibitor SureCN1652469 family 2 1
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Epidermal growth factor receptor ligand 4-Anilinopyrido[3,4-d]... 2 0
Epidermal growth factor receptor ligand (E)-5-[4-(3-bromoanili... 11 0
Epidermal growth factor receptor ligand (E)-1-[4-(3-bromoanili... 9 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 1 0
Epidermal growth factor receptor ligand AGN-PC-078X9P family 4 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 1 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00352981 CHEMBL281543 Bioactive N-[4-(3-chloro-4-fluoroanilino)-7-(4-morpholin-4-ylbutyl)pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide
CFAMM00352980 CHEMBL204085 Bioactive AGN-PC-00C7QM
CFAMM00352978 CHEMBL521601 Bioactive AGN-PC-078XBU
CFAMM00352977 CHEMBL490496 Bioactive N-[4-[(3-chloro-4-fluorophenyl)methyl]-7-[(E)-4-morpholin-4-ylbut-1-enyl]pyrido[3,2-d]pyrimidin-6-yl]prop-2-enamide
CFAMM00352976 CHEMBL203661 Bioactive AGN-PC-00BRQ3

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26814 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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