CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4109
Family Name Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-1-(4-tert-butylphenyl)sulfonyl-2-methyl-4-(1-pyridin-4-ylethyl)piperazine family
No. of Seeds 5 No. of Other Members 10
Family Centroid CFAMM00353024 Functional Category Bioactive with Natural Product
Superfamily Corticosteroid 11-beta-dehydrogenase isozyme 1 and Cannabinoid receptor 2 Binder Superfamily
Class Class 3565

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B ligand triptan Almotriptan Family 8 438
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
Prostaglandin G/H synthase 2 Inhibitor Etoricoxib Family 2 99
Solute carrier family 12 member 1 Inhibitor Torasemide Family 13 75
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
Rho-associated protein kinase 1 Inhibitor Rho-kinase Inhibitor... 6 39
E7820 family 9 56
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Coagulation factor X Inhibitor M55113 Family 1 8
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
5-hydroxytryptamine receptor 6 Ligand E-6837 Family 22 44
5-hydroxytryptamine receptor 6 Ligand 4-(4,6-dinitro-1h-indol-... 4 19
5-hydroxytryptamine receptor 6 Ligand 4-(1h-indol-1-ylsulfonyl... 7 79
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 1-methyl-1h... 6 24
Plasminogen and Urokinase-type plasminogen activator Inhibitor... 3 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 14 19
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 2-(4-... 8 25
Corticosteroid 11-beta-dehydrogenase isozyme 1 Inhibitor 1-(3-... 2 29
Carbonic anhydrase 2 and Carbonic anhydrase 9 Inhibitor Quinol... 4 13
5-hydroxytryptamine receptor 6 Ligand 6-tosyl-1,2,3,4,5,6-hexa... 4 22
Prostaglandin G/H synthase 1 Inhibitor 1-(4-aminosulfonylpheny... 3 18
Prostaglandin G/H synthase 2 Inhibitor 2-(4-(methylsulfonyl)ph... 7 33
C-C chemokine receptor type 5 ligand AC1LAJBP family 2 6
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 10 2
Neuropeptide Y receptor type 5 ligand 2-[4-(benzenesulfonamido... 2 27
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Nicotinamide phosphoribosyltransferase and Prelamin-A/C inhibi... 1 0
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[2-(... 2 6
Glucose-dependent insulinotropic receptor ligand AGN-PC-0A9QCI... 2 6
5-hydroxytryptamine receptor 6 ligand SureCN3411879 family 10 3
5-hydroxytryptamine receptor 6 and Muscarinic acetylcholine re... 7 3
5-hydroxytryptamine receptor 6 ligand 1-(4-chlorophenyl)sulfon... 8 4
Carbonic anhydrase 12 and Carbonic anhydrase 9 inhibitor 4-(4-... 1 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 1 4
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 12 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 0
Metabotropic glutamate receptor 5 ligand AGN-PC-00CRVW family 1 0
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 12 11
Bombesin receptor subtype-3 and Nuclear receptor subfamily 1 g... 3 0
5-hydroxytryptamine receptor 6 ligand 9-(benzenesulfonyl)-N,N-... 7 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 7 liga... 3 11
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 5 2
Nicotinamide phosphoribosyltransferase inhibitor N-[[4-(3,5-di... 4 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 1 3
5-hydroxytryptamine receptor 7 ligand 6-[(2R)-2-[2-(4-methylpi... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1,1,1... 12 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor [1-[4... 2 0
Cannabinoid receptor 1 ligand N-[[(3R,6S)-1-(4-chlorophenyl)-6... 2 0
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Carbonic anhydrase 9 and Carbonic anhydrase 2 inhibitor 4-[4-(... 3 0
Cytochrome P450 3A4 inhibitor N-[2-fluoro-4-(4-fluorophenyl)ph... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00353011 CHEMBL515876 Bioactive (2R)-1-(4-tert-butylphenyl)sulfonyl-2-methyl-4-(2-pyridin-4-ylethyl)piperazine
CFAMM00353019 CHEMBL491152 Bioactive (2R)-2-methyl-4-(2-pyridin-4-ylethyl)-1-[4-(1,1,1,2-tetrafluoropropan-2-yl)phenyl]sulfonylpiperazine
CFAMM00353024 CHEMBL473350 Bioactive (2R)-1-(4-tert-butylphenyl)sulfonyl-2-methyl-4-(1-pyridin-4-ylethyl)piperazine
CFAMM00353013 CHEMBL473954 Bioactive (2R)-1-(4-tert-butylphenyl)sulfonyl-2-methyl-4-(3-pyridin-4-ylpropyl)piperazine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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