CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

Family Name Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]-4-[2-(1,3-benzodioxol-5-yl)ethyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid family
No. of Seeds 3 No. of Other Members 6
Family Centroid CFAMM00311361 Functional Category Bioactive
Superfamily TGF-beta receptor type-1 and Telomerase reverse transcriptase Binder Superfamily
Class Class 1456

Cousin Family NamesSeedsMembers
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
DNA (cytosine-5)-methyltransferase 3B Inhibitor NSC-57893 Family 3 8
Thromboxane A2 receptor ligand AC1NSKJR family 13 42
Thyroid hormone receptor beta ligand CHEMBL1325165 family 1 6
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 4 29
Type-1 angiotensin II receptor ligand N-[2-(3-methoxyphenyl)et... 2 0
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07C5JC family 1 3
Tryptase alpha/beta-1 and Tryptase delta inhibitor AGN-PC-0763... 1 1
TGF-beta receptor type-1 ligand AGN-PC-07CRDB family 5 4


External ID

Functional Category

Molecule Name

CFAMM00311361 CHEMBL107983 Bioactive 2-[(2S)-7-[1H-benzimidazol-2-ylmethyl(methyl)carbamoyl]-4-[2-(1,3-benzodioxol-5-yl)ethyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00311360 CHEMBL110722 Bioactive 2-[(2S)-7-[5H-[1,3]dioxolo[4,5-f]benzimidazol-6-ylmethyl(methyl)carbamoyl]-4-methyl-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid
CFAMM00311366 CHEMBL108366 Bioactive 2-[(2S)-7-(1H-benzimidazol-2-ylmethylcarbamoyl)-4-[2-(1,3-benzodioxol-5-yl)ethyl]-3-oxo-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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