CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4177
Family Name Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor AC1L9U6J family
No. of Seeds 3 No. of Other Members 10
Family Centroid CFAMM00353492 Functional Category Bioactive
Superfamily Dihydrofolate reductase and Bifunctional dihydrofolate reductase-thymidylate synthase Binder Superfamily 4
Class Class 1144

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Histamine H1 receptor Ligand Astemizole Family 7 240
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
Serine/threonine-protein kinase Chk1 and Serine/threonine-prot... 23 121
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Tyrosine-protein kinase SYK Inhibitor R788 Family 3 7
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
Abelson tyrosine-protein kinase 2 and Proto-oncogene tyrosine-... 25 40
AP26113 family 16 90
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Platelet-derived growth factor receptor alpha and Platelet-der... 3 18
Reverse transcriptase Inhibitor UK-129485 Family 23 221
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Platelet-derived growth factor receptor beta and Platelet-deri... 2 19
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Aurora kinase A and Aurora kinase B inhibitor AGN-PC-00EQPZ fa... 3 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 11
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 14
Cellular tumor antigen p53 and Prelamin-A/C inhibitor CHEMBL14... 2 11
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Alpha-1A adrenergic receptor ligand 6,7-dimethoxy-2-[4-[(5-oxi... 3 1
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Dihydrofolate reductase inhibitor AC1LA5HU family 8 4
Dihydrofolate reductase inhibitor AC1L9XPA family 6 5
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 1 ligand 1-[3-[1-(cyclohexylmethy... 15 9
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 3 6
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Serine/threonine-protein kinase Chk2 and Serine/threonine-prot... 1 0
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 6 12
Insulin-like growth factor 1 receptor ligand 3qqu family 2 12
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Corticotropin-releasing factor receptor 1 ligand 3,6-diethyl-5... 7 8
Insulin receptor and Insulin-like growth factor 1 receptor lig... 17 7
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 3 1
Fatty-acid amide hydrolase 1 inhibitor [4-(4-methoxyphenyl)pip... 1 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 2
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 1 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 5 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 4 2
Cathepsin K and Cathepsin L1 inhibitor CHEBI:43424 family 2 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 16 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 5 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 5 8
Interleukin-1 receptor-associated kinase 4 and Interleukin-1 r... 4 0
Insulin-like growth factor 1 receptor ligand 4-(2,3-dihydroind... 1 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
ALK tyrosine kinase receptor and Insulin-like growth factor 1 ... 1 4
Dual specificity protein kinase TTK inhibitor 6-N-cyclohexyl-2... 12 2
Dual specificity protein kinase TTK inhibitor 2-[1-[4-[[6-(cyc... 8 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Focal adhesion kinase 1 inhibitor AGN-PC-00AVK6 family 1 1
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 2
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 14 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4716133 family 2 2
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Tyrosine-protein kinase Lck and Vascular endothelial growth fa... 2 2
Epidermal growth factor receptor ligand SureCN2989664 family 5 2
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Dihydrofolate reductase inhibitor AGN-PC-001U7R family 3 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VO0 family 1 0
Transient receptor potential cation channel subfamily V member... 18 1
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor AGN-... 1 0
5-hydroxytryptamine receptor 1A and Gonadotropin-releasing hor... 3 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 6 1
Glutaminyl-peptide cyclotransferase inhibitor 1-(3,4-dimethoxy... 1 17
LIM domain kinase 2 and LIM domain kinase 1 inhibitor SureCN36... 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Dihydrofolate reductase inhibitor 5-[3-(3-methoxy-5-morpholin-... 2 0
Serine/threonine-protein kinase PLK1 inhibitor SureCN3992071 f... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 2
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00353492 CHEMBL139485 Bioactive AC1L9U6J
CFAMM00353505 CHEMBL141698 Bioactive AC1L9U6D

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27043 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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