CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM425
Family Name D(4) dopamine receptor and D(2) dopamine receptor ligand 2-[4-[(5-chloro-2-propan-2-ylphenyl)methyl]piperazin-1-yl]-1-[(2R)-2-methyl-2,3-dihydroindol-1-yl]ethanone family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00305285 Functional Category Bioactive
Superfamily Nociceptin receptor and D(4) dopamine receptor Binder Superfamily
Class Class 220

Cousin Family NamesSeedsMembers
Benzodiazepine receptor ligand benzodiazepine derivative Fludi... 11 78
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Motilin receptor Ligand GSK962040 Family 30 457
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 23
Sigma non-opioid intracellular receptor 1 Ligand MS-377 Family 1 21
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 19 88
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Bifunctional epoxide hydrolase 2 Inhibitor N-(3-chloro-phenyl)... 2 43
Phospholipase D1 Inhibitor Halopemide Family 17 111
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand methy... 2 11
D(4) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 7 27
D(4) dopamine receptor and Alpha-1B adrenergic receptor ligand... 2 6
E3 ubiquitin-protein ligase Mdm2 inhibitor (2'R,3R,3'S,5'S)-6-... 17 51
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 ligand tert-butyl 4-[(3S)-4-[4-[2-[1-[... 2 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 4 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 10
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 3 6
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
Melanocortin receptor 4 ligand (3R)-N-[(2R)-3-(4-chlorophenyl)... 6 9
Melanin-concentrating hormone receptor 1 ligand 4-(4-chlorophe... 2 0
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
C-C chemokine receptor type 1 ligand SureCN3159355 family 7 9
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 5 2
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 8 4
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Melanin-concentrating hormone receptor 1 and Potassium voltage... 2 2
C-C chemokine receptor type 5 ligand AC1MHYGF family 3 2
Melanocortin receptor 4 ligand SureCN6183720 family 2 5
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 3 0
Growth hormone secretagogue receptor type 1 ligand N-[4,6-dich... 2 0
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor SureCN3726471 family 3 0
P2X purinoceptor 7 inhibitor AGN-PC-088GOO family 3 0
P2X purinoceptor 7 inhibitor SureCN3652462 family 5 2
P2X purinoceptor 7 inhibitor SureCN3721807 family 3 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 2
Translocator protein inhibitor CHEMBL2332254 family 6 1
Cannabinoid receptor 2 ligand 1-adamantyl-(5-fluoro-2,3-dihydr... 4 7
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Nociceptin receptor and Delta-type opioid receptor ligand spir... 25 9
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
Kappa-type opioid receptor ligand AGN-PC-077Q4Y family 5 9
Urotensin-2 receptor and Cytochrome P450 2D6 ligand 2-[3,4-dic... 2 3
Urotensin-2 receptor and Cytochrome P450 3A4 ligand 6,7-dichlo... 2 0
Kappa-type opioid receptor and Urotensin-2 receptor ligand 2-(... 5 1
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
5-hydroxytryptamine receptor 7 ligand 7-chloro-3-[4-[4-(4-chlo... 2 0
Mu-type opioid receptor and Nociceptin receptor ligand SureCN8... 7 1
Substance-K receptor and Neuromedin-K receptor ligand 1-benzyl... 3 10
Glutamate receptor ionotropic, NMDA 1 ligand CHEMBL40730 family 4 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[4-... 4 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 4 1
Sodium-dependent noradrenaline transporter inhibitor AGN-PC-07... 1 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 2 0
Progesterone receptor ligand CHEMBL403139 family 2 0
Somatostatin receptor type 1 ligand AGN-PC-078XL6 family 9 9
Somatostatin receptor type 1 ligand AGN-PC-078XL4 family 2 0
Sodium-dependent noradrenaline transporter and Sodium-dependen... 1 0
Progesterone receptor ligand SureCN3031001 family 8 40
D(1A) dopamine receptor and D(3) dopamine receptor ligand 1-[4... 1 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 0
Potassium voltage-gated channel subfamily H member 2 and D(3) ... 3 0
Sodium-dependent dopamine transporter and Sodium-dependent nor... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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