CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM42509
Family Name Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dimethyl-8-(7-oxofuro[3,2-g]chromen-4-yl)oxyoct-6-en-2-yl]oxy-3,7-dimethylocta-2,7-dienoxy]furo[3,2-g]chromen-7-one family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00519472 Functional Category Bioactive with Human Metabolite
Superfamily Cytochrome P450 3A4 inhibitor 4-[(2E)-6-[(E)-3-hydroxy-2,6-dimethyl-8-(7-oxofuro[3,2-g]chromen-4-yl)oxyoct-6-en-2-yl]oxy-3,7-dimethylocta-2,7-dienoxy]furo[3,2-g]chromen-7-one Superfamily
Class Class 1957

Cousin Family NamesSeedsMembers
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
DNA Binder Methoxsalen Family 10 1638
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Hidrosmin family 14 61
Ipriflavone family 62 2480
Rotenone family 16 107
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Endothelin-1 receptor Ligand PD156707 Family 41 211
Estrogen receptor beta Ligand 2-(4-hydroxy-phenyl)benzofuran-5... 5 82
Oestrogen receptor and Estrogen receptor beta Ligand 7-chloro-... 2 27
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Platelet-derived growth factor receptor beta Ligand Bis(5-meth... 5 220
Tyrosine-protein phosphatase non-receptor type 1 Ligand Licoag... 9 32
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
Tyrosine-protein phosphatase non-receptor type 1 and Neuramini... 10 2
Aromatase Inhibitor 3,4-bis(3,4-dimethoxyphenyl)furan-2(5h)-on... 4 86
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Prostaglandin G/H synthase 2 Inhibitor Neolignan 9-nor-7,8-deh... 1 7
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
Tyrosyl-DNA phosphodiesterase 1 and Microtubule-associated pro... 1 1
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Sodium-dependent serotonin transporter and Sodium-dependent do... 3 78
Survival motor neuron protein and Prelamin-A/C inhibitor CHEMB... 2 32
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Methionine aminopeptidase inhibitor 5-[2-(Trifluoromethoxy)phe... 1 0
Sodium/glucose cotransporter 2 inhibitor (2S,3R,4R,5S,6R)-2-[3... 1 4
Prothrombin inhibitor sodium;[3-ethoxycarbonyl-2-[[3-ethoxycar... 1 6
Arachidonate 5-lipoxygenase inhibitor AGN-PC-00OPWJ family 1 1
Cannabinoid receptor 1 and Cytochrome P450 3A4 ligand LY320135... 1 0
Prelamin-A/C and Inositol monophosphatase 1 inhibitor MLS00053... 1 1
Acenes Metabolite Aflatoxin B1 dialcohol Family 1 0
Benzopyrans Metabolite Erosnin Family 1 0
Benzofurans Metabolite (R)-Bitalin A Family 1 9
5,6-dihydro-4H-furo[2',3':3,4]cyclohepta[1,2-b][1]benzofuran N... 3 0
NP 2,2,11,12-tetramethyl-3,4,8,9-tetrahydro-2h-cyclopenta[c]fu... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00519473 CHEMBL1795443 Bioactive 2-[2-(3,5-difluorophenyl)-5,6-dihydrofuro[3,2-f][1]benzofuran-6-yl]propan-2-ol
CFAMM00519472 CHEMBL1743356 Bioactive 4-[(2E)-6-[(E)-3-hydroxy-2,6-dimethyl-8-(7-oxofuro[3,2-g]chromen-4-yl)oxyoct-6-en-2-yl]oxy-3,7-dimethylocta-2,7-dienoxy]furo[3,2-g]chromen-7-one
CFAMM00519471 CHEMBL1743357 Bioactive FC726

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27634 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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