CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4271
Family Name D(4) dopamine receptor and D(1A) dopamine receptor ligand 2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-indole-5-carbonitrile family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00354476 Functional Category Bioactive
Superfamily D(4) dopamine receptor and D(1A) dopamine receptor Binder Superfamily
Class Class 471

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 4 171
Glutamate dehydrogenase inhibitor quinoline derivative Chloroq... 7 189
Acetylcholinesterase Inhibitor Tacrine Family 12 515
D(2) dopamine receptor Ligand Sertindole Family 3 173
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
D(1B) dopamine receptor Ligand LE-300 Family 65 452
5-hydroxytryptamine receptor 2A Ligand RP-68303 Family 7 44
Nicotinic acetylcholine receptor Ligand Epibatidine Family 36 19
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
Potassium voltage-gated channel subfamily H member 2 Ligand 5-... 5 14
5-hydroxytryptamine receptor 2A Ligand 8-chloro-1,2,3,4-tetrah... 5 4
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 43 17
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 2
Cholinesterase Inhibitor 9-[9-(beta-carboline-9-yl)nonyl]-beta... 7 7
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 10 18
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 3-chlo... 3 2
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Histamine H3 receptor and Potassium voltage-gated channel subf... 3 3
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 1
Progesterone receptor and Androgen receptor ligand 5-[4-[(Z)-C... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Sodium-dependent serotonin transporter inhibitor SureCN6087392... 1 1
Prostaglandin G/H synthase 2 inhibitor SureCN6998947 family 1 1
Melatonin receptor type 1A and Melatonin receptor type 1C liga... 2 5
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 9 3
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Ceramide glucosyltransferase inhibitor AGN-PC-07YS0C family 4 3
Glucocorticoid receptor and Androgen receptor ligand AGN-PC-0A... 3 0
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
Sodium-dependent serotonin transporter and Sodium-dependent no... 5 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 0
Melanin-concentrating hormone receptor 2 and Sodium-dependent ... 2 1
5-hydroxytryptamine receptor 6 ligand 9-(2-bromophenyl)sulfony... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN5547533 f... 3 2
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 2 2
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 3 5
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 1 0
D(4) dopamine receptor and D(1A) dopamine receptor ligand AGN-... 1 0
Gamma-aminobutyric acid receptor subunit beta-3 and Gamma-amin... 2 5
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 1 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 1 2
Nociceptin receptor ligand AGN-PC-07C3R0 family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00354476 CHEMBL140594 Bioactive 2-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-indole-5-carbonitrile
CFAMM00354473 CHEMBL140006 Bioactive 2-[[4-(3,4-dichlorophenyl)piperazin-1-yl]methyl]-1H-indole-5-carbonitrile

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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