CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4294
Family Name Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL1433519 family
No. of Seeds 1 No. of Other Members 53
Family Centroid CFAMM00354880 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Beta-secretase 1 Binder Superfamily
Class Class 2030

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Dual specificity mitogen-activated protein kinase kinase Inhib... 8 4
K-604 family 4 71
Pan-DAC Inhibitor AR-42 Family 21 153
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(4-amino-phenyl)-8-... 4 35
Extracellular calcium-sensing receptor Ligand 3-phenethyl-2-ph... 3 137
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 7 35
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
Phospholipase D1 Inhibitor Halopemide Family 17 111
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Peptide deformylase, mitochondrial Inhibitor 2-allylthio-3-ben... 3 17
Poly [ADP-ribose] polymerase 1 Inhibitor 8-methyl-2-(4-nitro-p... 1 0
Arachidonate 5-lipoxygenase and Prostaglandin G/H synthase 1 I... 9 7
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 15 129
Ghrelin/growth hormone secretagogue receptor ligand AGN-PC-00A... 7 27
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 3
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 2 4
Coagulation factor VII inhibitor 3-amino-N-[(2R)-butan-2-yl]-5... 2 7
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-[[(2-hydroxy... 6 2
ALK tyrosine kinase receptor ligand 4-fluoro-N-[6-(piperidin-1... 10 7
Urokinase plasminogen activator surface receptor ligand 5,12-d... 1 0
Histone deacetylase 6 and Histone deacetylase 8 inhibitor (E)-... 2 8
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Mitogen-activated protein kinase 14 inhibitor 3-(2-amino-4-oxo... 1 2
Corticotropin-releasing factor receptor 1 ligand 5-chloro-1-[(... 9 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 2 2
Acetylcholinesterase and Cholinesterase inhibitor N-[4-[(E)-(6... 1 1
Carbonic anhydrase 9 and Carbonic anhydrase 12 inhibitor 4-oxo... 3 1
C-X-C chemokine receptor type 3 ligand N-[2-(dimethylamino)eth... 3 4
Peptidyl-prolyl cis-trans isomerase A inhibitor (3S,6S,9S,12R,... 2 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Telomerase reverse transcriptase inhibitor AGN-PC-07ZBGW family 2 0
Poly [ADP-ribose] polymerase 1 inhibitor 8-amino-1H-quinazolin... 1 2
Prostaglandin E synthase inhibitor 2-chloro-N-[3-[[4-(3-chloro... 5 0
Beta-secretase 1 inhibitor 3-(2-Amino-6-Benzoylquinazolin-3(4h... 1 0
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 12


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00354890 CHEMBL2031227 Bioactive 4-cyano-N-[4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3-yl]phenyl]benzamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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