| Cousin Family Names | Seeds | Members |
|---|
| Mast/stem cell growth factor receptor Kit and Abelson tyrosine... | 6 | 537 |
| 5-hydroxytryptamine receptor 3A Ligand Granisetron Family | 26 | 212 |
| Prothrombin Inhibitor Dabigatran Family | 7 | 182 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 5 | 129 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... | 28 | 56 |
| Dipeptidyl peptidase 4 Inhibitor Linagliptin Family | 10 | 81 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family | 53 | 580 |
| Vascular endothelial growth factor receptor 1 and Angiopoietin... | 29 | 127 |
| Histone deacetylase 6 Inhibitor ACY-1215 Family | 10 | 230 |
| PHA848125 family | 13 | 138 |
| TGF-beta receptor type-1 Ligand LY2157299 Family | 13 | 56 |
| Smoothened homolog Inhibitor LY2940680 Family | 3 | 18 |
| JAK Inhibitor Momelotinib Family | 33 | 83 |
| C-C chemokine receptor type 3 Ligand YM-344031 Family | 19 | 106 |
| XL-888 family | 16 | 85 |
| Platelet activating factor, putative Inhibitor ABT-491 Family | 22 | 62 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 11 | 138 |
| Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... | 7 | 117 |
| Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... | 2 | 5 |
| Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... | 4 | 23 |
| 5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... | 19 | 103 |
| Aurora kinase B and Aurora kinase C Inhibitor PHA-680632 Family | 5 | 72 |
| Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... | 3 | 35 |
| Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... | 5 | 10 |
| Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... | 2 | 9 |
| Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... | 28 | 47 |
| Adenosine receptor A3 Ligand 2-benzyl-2h-pyrazolo[3,4-c]quinol... | 3 | 11 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand OSIP-3... | 4 | 31 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 24 | 79 |
| Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... | 6 | 37 |
| Gamma-aminobutyric acid receptor subunit alpha-1 Ligand N-(9h-... | 5 | 2 |
| Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... | 2 | 10 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... | 2 | 11 |
| Vasopressin V2 receptor Ligand YM-35278 Family | 33 | 38 |
| RAC-gamma serine/threonine-protein kinase Inhibitor BMS-754807... | 20 | 90 |
| Serine/threonine-protein kinase B-raf Inhibitor Pyrazolo[1,5-a... | 7 | 77 |
| Prothrombin inhibitor 2-[(2S)-1-[(2R)-2-amino-3-phenylpropanoy... | 3 | 16 |
| 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... | 8 | 12 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 2 | 4 |
| Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... | 1 | 8 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZYJE fa... | 15 | 5 |
| Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... | 8 | 7 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand [(7R)... | 10 | 10 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand SureC... | 2 | 3 |
| Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... | 10 | 5 |
| Mitogen-activated protein kinase 13 inhibitor N-cyclopropyl-3-... | 16 | 40 |
| Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... | 3 | 18 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... | 5 | 1 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07ZE3... | 6 | 1 |
| Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07RDWA fa... | 1 | 4 |
| Platelet-activating factor receptor ligand SureCN9384429 family | 11 | 3 |
| Smoothened homolog inhibitor SureCN1091571 family | 2 | 2 |
| Serine/threonine-protein kinase D1 and Polycystin-2 inhibitor ... | 3 | 7 |
| Mitogen-activated protein kinase 14 inhibitor 3mvm family | 6 | 1 |
| TGF-beta receptor type-1 ligand 6-[4-ethyl-2-(6-methylpyridin-... | 9 | 11 |
| DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... | 2 | 10 |
| Mitogen-activated protein kinase 14 inhibitor N-cyclopropyl-4-... | 4 | 10 |
| Mitogen-activated protein kinase kinase kinase kinase 5 and Du... | 1 | 18 |
| Adenosine receptor A1 ligand AGN-PC-07PMLW family | 6 | 4 |
| Cell division cycle 7-related protein kinase inhibitor pyrrolo... | 4 | 10 |
| Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-09M6D1 family | 2 | 5 |
| Adenosine receptor A3 ligand N-(5-methyl-2-phenylpyrazolo[4,3-... | 5 | 8 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... | 8 | 7 |
| Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... | 12 | 3 |
| Type-1 angiotensin II receptor and Type-2 angiotensin II recep... | 3 | 6 |
| Adenosine receptor A2a ligand AGN-PC-077RWY family | 4 | 5 |
| Coagulation factor X and Trypsin-1 inhibitor SureCN3836037 family | 5 | 4 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 7 | 9 |
| Inositol monophosphatase 1 and 15-hydroxyprostaglandin dehydro... | 1 | 0 |
| Survival motor neuron protein and Muscleblind-like protein 1 i... | 1 | 3 |
| Survival motor neuron protein inhibitor CHEMBL1583999 family | 1 | 3 |
| 3-phosphoinositide-dependent protein kinase 1 and Rho-associat... | 12 | 11 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QJGR family | 3 | 13 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 0 |
| Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 1 | 1 |
| Aurora kinase A inhibitor AGN-PC-00EHLC family | 1 | 0 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 1 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-09QGLU family | 3 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta inhibi... | 34 | 4 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family | 8 | 15 |
| Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07CBUP family | 2 | 3 |
| Serine/threonine-protein kinase mTOR inhibitor AGN-PC-093LHN f... | 3 | 2 |
| D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 4 | 1 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... | 1 | 4 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor dihydro-benz... | 3 | 5 |
| Mitogen-activated protein kinase 9 and MAP kinase-activated pr... | 1 | 0 |
| Mitogen-activated protein kinase 14 inhibitor N-ethyl-5-methyl... | 17 | 3 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 13 | 3 |
| Histone deacetylase 1 inhibitor (E)-N-hydroxy-3-[4-[[2-(2-meth... | 7 | 9 |
| Beta-secretase 1 and Beta-secretase 2 inhibitor (5S)-2-amino-5... | 3 | 39 |
| Coagulation factor X inhibitor AGN-PC-0749BY family | 5 | 9 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 14 | 2 |
| B1 bradykinin receptor ligand 6-(8-fluoro-4-methyl-1-oxophthal... | 3 | 0 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 2 | 3 |
| Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... | 1 | 0 |
| TGF-beta receptor type-1 ligand 3-[[3-(6-methylpyridin-2-yl)-4... | 1 | 0 |
| Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 2 | 0 |
| Protein-tyrosine kinase 6 and KH domain-containing, RNA-bindin... | 21 | 6 |
| Coagulation factor X and Coagulation factor IX inhibitor pyraz... | 11 | 0 |
| Coagulation factor X and Coagulation factor IX inhibitor pyraz... | 6 | 1 |
| 5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... | 2 | 18 |
| Heat shock protein HSP 90-beta inhibitor N-[(9R)-4-(3H-imidazo... | 1 | 0 |
| Hepatocyte growth factor receptor ligand 5-[[6-(1-methylpyrazo... | 4 | 0 |
| Rho-associated protein kinase 2 and Rho-associated protein kin... | 2 | 6 |
| Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-[1-(pyri... | 5 | 11 |
| MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... | 25 | 1 |
| Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... | 11 | 3 |
| 5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 3 | 2 |
| Mitogen-activated protein kinase 14 inhibitor ethyl N-[4-[5-(m... | 5 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 3 | 1 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 5 | 4 |
| 5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... | 3 | 1 |
| 5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 10 | 0 |
| Mast/stem cell growth factor receptor Kit and Receptor-type ty... | 8 | 3 |
| Cell division cycle 7-related protein kinase and Casein kinase... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor methyl 4-[5-(eth... | 3 | 11 |
| Insulin-like growth factor 1 receptor and Mitogen-activated pr... | 3 | 4 |
| Aurora kinase B and Aurora kinase A inhibitor 4-amino-N-[3-[[(... | 5 | 3 |
| Aurora kinase B and Aurora kinase A inhibitor (2S)-1-[4-[[1-[(... | 12 | 4 |
| Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... | 4 | 0 |
| Dipeptidyl peptidase 4 inhibitor 2-[[2-[(3R)-3-aminopiperidin-... | 1 | 0 |
| Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... | 6 | 0 |
| Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... | 4 | 2 |
| DNA gyrase subunit B inhibitor 5-[2-(ethylcarbamoyl)-4-[3-(tri... | 2 | 4 |
| Casein kinase II subunit alpha and Homeodomain-interacting pro... | 5 | 0 |
| Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... | 3 | 0 |
| Aurora kinase A and Aurora kinase B inhibitor 4-amino-N-[4-(th... | 1 | 1 |
| Cyclin-dependent kinase 2 and Serine/threonine-protein kinase ... | 2 | 2 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor (2... | 16 | 5 |
| Coagulation factor X inhibitor AGN-PC-02WFR7 family | 7 | 13 |
| Melanin-concentrating hormone receptor 1 ligand 6-(4-chlorophe... | 8 | 1 |
| Renin inhibitor AGN-PC-073MLF family | 7 | 6 |
| Succinate receptor 1 ligand N-[[4-(3-methylphenyl)phenyl]methy... | 2 | 14 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 6 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 1 |
| Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... | 12 | 0 |
| Tyrosine-protein kinase SYK and Potassium voltage-gated channe... | 1 | 0 |
| Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... | 17 | 0 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase ITK/TS... | 4 | 0 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 3 | 1 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 5 | 6 |
| Vascular endothelial growth factor receptor 2 and Angiopoietin... | 14 | 0 |
| Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... | 4 | 8 |
| Serine/threonine-protein kinase Chk1 inhibitor SureCN14402832 ... | 6 | 5 |
| Serine/threonine-protein kinase TBK1 inhibitor N-[3-[[5-cyclop... | 3 | 0 |
| P2X purinoceptor 7 inhibitor SureCN109149 family | 8 | 1 |
| cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... | 3 | 0 |
| Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... | 6 | 0 |
| Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... | 3 | 0 |
| Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... | 7 | 1 |
| Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-fluoro... | 5 | 1 |
| Metabotropic glutamate receptor 5 ligand 5-(4-chlorophenyl)-1,... | 3 | 1 |
| Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... | 12 | 3 |
| Serine/threonine-protein kinase PLK4 inhibitor (3E)-3-[[3-[(E)... | 5 | 2 |
| Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... | 3 | 0 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... | 9 | 2 |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor 4-[4... | 1 | 1 |
| Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... | 5 | 13 |
| Casein kinase II subunit alpha inhibitor CHEMBL401945 family | 12 | 1 |
| Mitogen-activated protein kinase 14 inhibitor 3-[(6-amino-1-ph... | 9 | 2 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 3 | 1 |
| Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... | 3 | 0 |
| Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 0 |
| Alpha-1B adrenergic receptor and Alpha-1A adrenergic receptor ... | 2 | 0 |
| Mitogen-activated protein kinase 13 and Mitogen-activated prot... | 4 | 2 |
| Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... | 3 | 2 |
| Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... | 2 | 0 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 5 | 1 |
| Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... | 12 | 7 |
| Glucocorticoid receptor ligand N-[2-[[[5-amino-1-(4-fluorophen... | 1 | 0 |
| Rho-associated protein kinase 1 and Ribosomal protein S6 kinas... | 4 | 2 |
| Mast/stem cell growth factor receptor Kit and Tyrosine-protein... | 4 | 1 |
| Aurora kinase A and Aurora kinase B inhibitor N-[(3E)-3-[5-(mo... | 3 | 2 |
| Melanin-concentrating hormone receptor 1 ligand SureCN3834858 ... | 2 | 1 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 2 | 0 |
| Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family | 1 | 4 |
| Poly [ADP-ribose] polymerase 1 and Poly [ADP-ribose] polymeras... | 4 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-07R6O8 family | 5 | 2 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor AGN-PC-07B2Q... | 6 | 0 |
| Type-1 angiotensin II receptor ligand 2-[[(5-ethylpyrazolo[1,5... | 1 | 0 |
| Tyrosine-protein kinase receptor TYRO3 ligand 3-amino-6-(1H-in... | 2 | 3 |
| RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... | 1 | 0 |
| P2X purinoceptor 7 inhibitor N-cyano-N'-(2-methylphenyl)-4-[2-... | 2 | 1 |
| Cyclin-A2 and Cyclin-dependent kinase 2 inhibitor N-[5-(2,2-di... | 2 | 1 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
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2014.08.29
|
