CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4315
Family Name Substance-P receptor ligand AGN-PC-075NP5 family
No. of Seeds 4 No. of Other Members 8
Family Centroid CFAMM00355063 Functional Category Bioactive
Superfamily 72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhibitor SR-973 Superfamily
Class Class 2316

Cousin Family NamesSeedsMembers
D(2) dopamine receptor Ligand Remoxipride Family 12 84
Sodium channel protein type 5 subunit alpha Ligand Flecainide ... 2 162
Angiotensin-converting enzyme Inhibitor Moexipril Family 5 469
Synaptic vesicular amine transporter Inhibitor Tetrabenazine F... 13 425
Zucapsacin family 7 177
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Substance-P receptor Ligand Ezlopitant Family 10 207
Elagolix family 43 98
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
Delta-type opioid receptor Ligand Bw 373u86 Family 31 146
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
C-C chemokine receptor type 5 Ligand E-913 Family 6 44
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 4
Histamine H3 receptor Ligand A-349821 Family 49 228
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Mitogen-activated protein kinase 14 Inhibitor N-(4-(trifluorom... 8 39
Cannabinoid receptor 1 Ligand N-(4-methoxyphenethyl)oleamide F... 10 36
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 5 26
Acetylcholinesterase and Cholinesterase Inhibitor Caproctamine... 7 17
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Fatty-acid amide hydrolase 1 Inhibitor 3'-carbamoylbiphenyl-3-... 8 50
Urotensin-2 receptor Ligand SB-436811 Family 6 71
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 95 46
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 2 0
D(4) dopamine receptor and D(3) dopamine receptor ligand N-[(3... 2 11
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 1 13
Histamine H3 receptor ligand 1-(4-pentan-3-ylpiperazin-1-yl)-2... 1 1
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
3-hydroxyacyl-CoA dehydrogenase type-2 and Retinal dehydrogena... 1 15
Substance-P receptor ligand AGN-PC-075NSQ family 9 3
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 1
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 10
Carbonic anhydrase 9 and Carbonic anhydrase 14 inhibitor N-[2-... 6 10
Stromelysin-1 and Matrix metalloproteinase-9 inhibitor AGN-PC-... 26 12
Sigma non-opioid intracellular receptor 1 and D(2) dopamine re... 11 2
Pol polyprotein inhibitor CHEMBL305466 family 4 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 11 6
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylphenoxy)-... 10 0
Growth hormone secretagogue receptor type 1 ligand tert-butyl ... 5 4
Growth hormone secretagogue receptor type 1 ligand 2-(2-acetyl... 2 0
Vasopressin V1a receptor ligand 1-(4-chlorophenyl)-N-[(2R)-1-[... 2 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 3
Orexin receptor type 1 and Orexin receptor type 2 ligand [(2S)... 3 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 7 4
Cathepsin K and Cathepsin L1 inhibitor 4-ethyl-N-[(2S)-1-[2-(4... 7 10
NS3 inhibitor Proline-Based Macrocycle 24 family 6 6
Growth hormone secretagogue receptor type 1 ligand 2-[(2S)-1-[... 2 0
Nociceptin receptor and Kappa-type opioid receptor ligand AGN-... 1 3
Cathepsin K and Cathepsin S inhibitor (1R,2R)-N-[cyano-(2-meth... 1 0
Mu-type opioid receptor and Delta-type opioid receptor ligand ... 15 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 2 8
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 3
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
C-C motif chemokine 2 inhibitor (1S,3R)-N-[[3,5-bis(trifluorom... 3 4
Melanocortin receptor 4 ligand [(3R,4S)-4-(4-chlorophenyl)-1-p... 5 8
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 2 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 1 3
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 2 0
C-C chemokine receptor type 3 and C-C chemokine receptor type ... 3 4
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 15
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 7 1
Sigma non-opioid intracellular receptor 1 and D(3) dopamine re... 26 8
Integrin beta-3 and Integrin alpha-IIb inhibitor (3R)-3-(1,3-b... 4 2
Melanocortin receptor 4 and Melanocortin receptor 5 ligand 3-a... 2 2
Melanin-concentrating hormone receptor 1 ligand N-methyl-N-[(3... 2 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Renin inhibitor (1R,5S)-N-[(2-chlorophenyl)methyl]-7-[4-[3-[(2... 9 0
Beta-secretase 1 inhibitor 1-N-[(2S,3R)-1-(3,5-difluorophenyl)... 8 7
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04X9O... 2 1
C-C chemokine receptor type 5 ligand (4-chlorophenyl) N-[1-[(4... 2 2
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Muscarinic acetylcholine receptor M3 ligand N-[[3-[3-[(3-methy... 5 2
Neuropeptide Y receptor type 1 and Sodium-dependent serotonin ... 2 7
Renin inhibitor N-[(2S,3S,5R)-2-amino-6-(butylamino)-3-hydroxy... 5 1
C-C chemokine receptor type 3 and Probable C-C chemokine recep... 5 2
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
Dipeptidyl peptidase 4 inhibitor SureCN664019 family 4 5
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 1 1
Substance-P receptor ligand (2S)-N-[(2S)-1-[benzyl(methyl)amin... 2 2
Beta-lactamase and Histone-lysine N-methyltransferase 2A inhib... 1 7
Sterol O-acyltransferase 1 inhibitor AGN-PC-073SE1 family 1 0
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor Tetracycl... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355057 CHEMBL335624 Bioactive AGN-PC-075NTJ
CFAMM00355063 CHEMBL433683 Bioactive AGN-PC-075NP5
CFAMM00355061 CHEMBL140299 Bioactive AGN-PC-075NTM
CFAMM00355059 CHEMBL343797 Bioactive AGN-PC-03ITPF

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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