CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM43204
Family Name Peroxisome proliferator-activated receptor alpha and Peroxisome proliferator-activated receptor gamma ligand SureCN2383753 family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00521312 Functional Category Bioactive
Superfamily Lipoprotein lipase Inhibitor Gemfibrozil Superfamily
Class Class 164

Cousin Family NamesSeedsMembers
Thyroid hormone receptor alpha ligand thyroid hormone analog L... 10 61
Histamine H1 receptor Ligand Doxepin Family 8 89
Lipoprotein lipase Inhibitor Gemfibrozil Family 1 28
Prostaglandin F2-alpha receptor ligand prostaglandin analog Tr... 4 35
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Tyrosinase Inhibitor Monobenzone Family 6 197
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Ipriflavone family 62 2480
Enprostil family 1 2
Agrimophol family 10 22
Salicin family 5 629
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 6 33
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Free fatty acid receptor 1 Ligand TAK-875 Family 2 54
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Prostaglandin G/H synthase 1 Inhibitor (3-chloro-4-propoxy-phe... 2 10
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Cytosolic phospholipase A2 Inhibitor 1,1,1-trifluoro-6-(4-hexy... 9 86
Steryl-sulfatase Inhibitor 4-sulfamoyloxy-benzoic Acid Hexyl E... 11 1
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor 7-(b... 4 42
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 4 127
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Matrix metalloproteinase-9 and Collagenase 3 Inhibitor 4-amino... 1 8
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 1 and Prostaglandin G/H synthase 2 ... 3 0
Tyrosinase Inhibitor 3-(2,4-dihydroxyphenyl)-propionic Acid Et... 3 8
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
Amine oxidase [flavin-containing] A and Amine oxidase [flavin-... 3 27
Sodium/glucose cotransporter 2 and Sodium/glucose cotransporte... 3 19
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Squalene synthase inhibitor (6R,7R)-1-[(4S,5R)-4-acetyloxy-5-m... 8 5
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 4
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Neuropeptide Y receptor type 5 and Thioredoxin glutathione red... 13 6
G2/mitotic-specific cyclin-B1 and Cyclin-dependent kinase 1 in... 2 8
NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydr... 2 0
NS5B protein inhibitor SureCN3988565 family 2 4
Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-su... 2 3
Thyroid hormone receptor beta and Thyroid hormone receptor alp... 1 1
Benzoxepines Metabolite 4,5-Dihydro-1-benzoxepin-3(2H)-one Family 1 2
Phenylacetic Acid Derivatives Metabolite Guaicyl phenylacetate... 1 3
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
Putative NP ZINC31165975 Family 4 0
Putative NP ZINC04043753 Family 8 6
benzofuran-2-one NP 5-hydroxybenzofuran-2(3h)-one Family 1 0
2-(2-methoxyphenyl)-5-oxooxolane-3-carboxylate NP ZINC00132596... 4 2
2-methyl-2H-chromene-3-carbaldehyde NP 2-methyl-2h-chromene-3-... 2 1
3-pentyl-5-(phenoxymethyl)oxolan-2-one NP ZINC02116245 Family 4 0
NP (2r,3r,4s,5r,6s)-2-(acetoxymethyl)-6-(2-propionylphenoxy)te... 2 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00521312 CHEMBL194698 Bioactive SureCN2383753
CFAMM00521315 CHEMBL197268 Bioactive AGN-PC-00AIWO

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27058 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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