CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM43257
Family Name NS5B protein inhibitor (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydroxy-2-oxobut-3-enoic acid family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00521419 Functional Category Bioactive
Superfamily Glutamate carboxypeptidase 2 Inhibitor 3-(1-carboxy-4-mercaptobutoxy)benzoic Acid Superfamily
Class Class 366

Cousin Family NamesSeedsMembers
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Tyrosinase Inhibitor Monobenzone Family 6 197
Muscarinic acetylcholine receptor M1 Ligand GSK1034702 Family 7 148
Arachidonate 15-lipoxygenase Inhibitor Isoscopoletin Family 5 98
Carbonic anhydrase 9 and Carbonic anhydrase 12 Inhibitor Ethox... 12 80
Thyroid hormone receptor beta Ligand 2-hexylphenyl Acrylate Fa... 4 83
Kappa-type opioid receptor Ligand Anisocoumarin H Family 3 5
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Histone deacetylase 2 and Histone deacetylase 8 inhibitor AC1L... 2 2
Free fatty acid receptor 1 ligand 3-[4-[2-[2-(cyanomethoxy)phe... 1 2
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 2 4
Phenols and Derivatives Metabolite 2-(Ethoxymethyl)phenol Family 1 14
NP 4-(chloromethyl)-6-methoxy-2h-chromen-2-one Family 4 2


External ID

Functional Category

Molecule Name

CFAMM00521420 CHEMBL196447 Bioactive (Z)-4-[2-(3-cyanopropoxy)-5-hydroxyphenyl]-4-hydroxy-2-oxobut-3-enoic acid
CFAMM00521419 CHEMBL196154 Bioactive (Z)-4-[2-(3-cyanopropoxy)phenyl]-4-hydroxy-2-oxobut-3-enoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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