CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4327
Family Name B2 bradykinin receptor ligand SureCN6640854 family
No. of Seeds 7 No. of Other Members 4
Family Centroid CFAMM00355135 Functional Category Bioactive
Superfamily B2 bradykinin receptor Binder Superfamily
Class Class 297

Cousin Family NamesSeedsMembers
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
B2 bradykinin receptor Ligand Anatibant Family 49 15
Arachidonate 5-lipoxygenase-activating protein Inhibitor DG031... 3 206
Hepatocyte growth factor receptor and Vascular endothelial gro... 28 178
Multidrug resistance protein Inhibitor Tariquidar Family 3 60
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
Smoothened homolog Inhibitor LDE225 Family 3 76
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Peroxisome proliferator-activated receptor gamma and Peroxisom... 15 94
Aromatase Inhibitor 2-phenyl-3-pyridin-4-ylmethylene-chroman-4... 3 30
Platelet-derived growth factor receptor alpha and Platelet-der... 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAF proto-oncogene serine/threonine-protein kinase Inhibitor 5... 3 7
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
B2 bradykinin receptor Ligand FR-173657 Family 44 180
Renin Inhibitor CP-305202 Family 9 30
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 1 4
Acetylcholinesterase Inhibitor Lysicamine Family 2 8
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 22 57
Neuromedin-K receptor and Substance-K receptor ligand 2-[2-phe... 2 2
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK1 ... 5 25
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 21
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 18
B2 bradykinin receptor ligand SureCN6578325 family 2 1
B2 bradykinin receptor ligand (E)-N-[2-[2,4-dimethoxy-N-methyl... 3 2
B2 bradykinin receptor ligand 2-(4-aminobutylcarbamoylamino)-N... 5 0
B2 bradykinin receptor ligand (E)-3-(4-methoxyphenyl)-N-[2-[N-... 2 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... 4 24
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... 2 7
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Cysteinyl leukotriene receptor 1 ligand 4-[(2S)-2-[[7-(quinoli... 6 15
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cysteinyl leukotriene receptor 1 ligand SureCN7808360 family 4 11
Cysteinyl leukotriene receptor 1 ligand SureCN9053715 family 2 11
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
B2 bradykinin receptor ligand SureCN7012818 family 1 2
B2 bradykinin receptor ligand SureCN7749611 family 4 1
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family 5 33
B2 bradykinin receptor ligand 4-[(E)-3-[[2-[2,4-dichloro-3-[[4... 29 2
Prelamin-A/C inhibitor CHEMBL1374443 family 1 6
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 4
B2 bradykinin receptor ligand (E)-3-[6-(2-oxopyrrolidin-1-yl)p... 3 2
B2 bradykinin receptor ligand SureCN8516699 family 3 2
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Thyroid hormone receptor beta ligand CHEMBL1397256 family 1 12
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QHF0 family 3 1
Cysteinyl leukotriene receptor 2 and Cysteinyl leukotriene rec... 16 5
Somatostatin receptor type 2 ligand SureCN4325675 family 3 1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Cysteinyl leukotriene receptor 1 and Peripheral myelin protein... 1 1
Melanin-concentrating hormone receptor 1 ligand N-[3-(2-aminoq... 4 1
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075FSU ... 1 1
Cysteinyl leukotriene receptor 1 ligand 7-[[3-(quinolin-2-ylme... 7 5
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Platelet-derived growth factor receptor beta and Macrophage co... 1 4
Arachidonate 5-lipoxygenase-activating protein inhibitor methy... 12 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-[(1... 2 0
Arachidonate 5-lipoxygenase-activating protein inhibitor 2-met... 3 0
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 14 24
Disintegrin and metalloproteinase domain-containing protein 17... 13 3
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 12 0
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Prostaglandin E synthase inhibitor 3-[4-(3-cyanopropoxy)-3-met... 2 4
Cholinesterase and Acetylcholinesterase inhibitor 6-[4-[2-fluo... 17 0
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 11 7
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 19 11
Vascular endothelial growth factor receptor 2 ligand 6-(6,7-di... 4 0
Caspase-1 inhibitor (3S)-3-[[2-[3-(naphthalene-2-carbonylamino... 1 0
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Vascular endothelial growth factor receptor 2 ligand N-(4-chlo... 4 4
B2 bradykinin receptor ligand AGN-PC-073GJI family 2 4
B2 bradykinin receptor ligand SureCN7976932 family 2 0
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Type-1 angiotensin II receptor ligand 2-[(2-methyl-5,6,7,8-tet... 5 0
Pol polyprotein inhibitor Tertiary Amide deriv. 58 family 1 0
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Oxysterols receptor LXR-beta and Oxysterols receptor LXR-alpha... 4 3
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor ligand 4-[(E)-3-[[1-[2,4-dichloro-3-[(4... 3 0
cGMP-specific 3',5'-cyclic phosphodiesterase and Calcium/calmo... 7 2
B2 bradykinin receptor ligand (E)-N-[2-[N-methyl-3-[(2-methylq... 2 0
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
Prothrombin inhibitor AGN-PC-074I2Z family 2 1
Proteinase-activated receptor 1 ligand 2-[2-[(E)-2-[(3R,3aS,4S... 1 2
Potassium-transporting ATPase alpha chain 1 and Potassium-tran... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355137 CHEMBL544720 Bioactive N-methyl-4-[(E)-3-oxo-3-[[2-oxo-2-[N,2,4-trimethyl-3-[(2-methyl-4-phenylquinolin-8-yl)oxymethyl]anilino]ethyl]amino]prop-1-enyl]benzamide;hydrochloride
CFAMM00355130 CHEMBL323693 Bioactive SureCN6576314
CFAMM00355136 CHEMBL544622 Bioactive 4-[[2-[[(E)-3-[4-(dimethylcarbamoyl)phenyl]prop-2-enoyl]amino]acetyl]-methylamino]-1-N,1-N,3-N,3-N-tetramethyl-2-[(2-methylquinolin-8-yl)oxymethyl]benzene-1,3-dicarboxamide;hydrochloride
CFAMM00355129 CHEMBL552543 Bioactive (E)-3-[4-(2-oxopyrrolidin-1-yl)phenyl]-N-[2-oxo-2-[N,2,4-trimethyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]ethyl]prop-2-enamide;hydrochloride
CFAMM00355135 CHEMBL143697 Bioactive SureCN6640854
CFAMM00355127 CHEMBL543781 Bioactive N-methyl-4-[(E)-3-oxo-3-[[2-oxo-2-[N,2,4-trimethyl-3-[(2-methylquinolin-8-yl)oxymethyl]anilino]ethyl]amino]prop-1-enyl]benzamide;hydrochloride
CFAMM00355132 CHEMBL140383 Bioactive SureCN7012778

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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