CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM433
Family Name Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(4-fluorophenyl)pyrrolidine-1,2-dicarboxamide family
No. of Seeds 6 No. of Other Members 3
Family Centroid CFAMM00277904 Functional Category Bioactive
Superfamily Substance-P receptor and C-C chemokine receptor type 3 Binder Superfamily
Class Class 2044

Cousin Family NamesSeedsMembers
5-alpha reductase inhibitor azasteroid derivative Dutasteride ... 36 124
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Motilin receptor Ligand GSK962040 Family 30 457
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
B2 bradykinin receptor Ligand Quinapril Analogue Family 1 8
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 3 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-anil... 1 2
Disintegrin and metalloproteinase domain-containing protein 17... 1 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 6
Melanin-concentrating hormone receptor 1 ligand 1-[2-[4-(3-cya... 3 2
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Kappa-type opioid receptor ligand (2R)-6-amino-2-[[(2R)-2-[[(2... 2 1
C-C chemokine receptor type 3 ligand 4-(5-amino-2-oxo-3H-benzi... 1 0
C-C chemokine receptor type 3 ligand (2S)-1-N-[(1R,5R)-8-[(6-f... 1 1
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 4 7
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Translocator protein inhibitor CHEMBL2332254 family 6 1
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 11 4
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 3 5
Coagulation factor VII and Prothrombin inhibitor 2-[(4-carbami... 2 1
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 2 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-04XL6C family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311505 CHEMBL318084 Bioactive (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(3-cyanophenyl)pyrrolidine-1,2-dicarboxamide
CFAMM00311498 CHEMBL110355 Bioactive (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(2-fluorophenyl)pyrrolidine-1,2-dicarboxamide
CFAMM00311504 CHEMBL318085 Bioactive (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(2-cyanophenyl)pyrrolidine-1,2-dicarboxamide
CFAMM00311502 CHEMBL320581 Bioactive (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(3-fluorophenyl)pyrrolidine-1,2-dicarboxamide
CFAMM00311501 CHEMBL321554 Bioactive (2S)-2-N-[(2S)-1-[benzyl(methyl)amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]-1-N-(4-cyanophenyl)pyrrolidine-1,2-dicarboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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