CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4346
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN7971416 family
No. of Seeds 3 No. of Other Members 0
Family Centroid CFAMM00355311 Functional Category Bioactive
Superfamily Hepatocyte growth factor receptor and Proto-oncogene tyrosine-protein kinase ROS Inhibitor Crizotinib Superfamily
Class Class 795

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Avanafi... 3 16
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Corticotropin-releasing factor receptor 1 Ligand GW876008 Family 3 30
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
Vascular endothelial growth factor receptor 2 Ligand L00002164... 6 23
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Corticotropin-releasing factor receptor 1 Ligand BMS-561388 Fa... 10 16
Serine/threonine-protein kinase B-raf inhibitor SureCN1015955 ... 17 18
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 3 4
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YMN ... 7 11
Serine/threonine-protein kinase B-raf inhibitor SureCN1013580 ... 2 0
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-072YXQ ... 2 1
Adenosine receptor A3 ligand CHEMBL1834696 family 5 18
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 23 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 31 11
Cellular tumor antigen p53 inhibitor CHEMBL1401545 family 1 25
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 5 1
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Corticotropin-releasing factor receptor 1 ligand CHEMBL1830528... 1 0
TGF-beta receptor type-1 ligand N-(4-methoxyphenyl)-3-(6-methy... 5 2
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 4 9
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Metabotropic glutamate receptor 2 ligand 8-chloro-3-(cycloprop... 6 2
Adenosine receptor A1 ligand ethyl 1-(2-chloro-2-phenylethyl)-... 5 1
Acyl-CoA desaturase 1 inhibitor 3-[4-(2-chlorophenoxy)piperidi... 1 0
Tyrosine-protein kinase JAK2 inhibitor (2R)-2-[4-[[8-(4-methox... 2 0
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 14 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 5 0
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 4 0
Acyl-CoA desaturase 1 inhibitor Pyridazine, 3-[4-(2-ethylpheno... 4 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355313 CHEMBL410215 Bioactive SureCN7958192
CFAMM00355312 CHEMBL344018 Bioactive 9-N-[(3-chloro-4-methoxyphenyl)methyl]-3-ethyl-6-N-(pyridin-4-ylmethyl)pyrazolo[4,5]pyrido[1,2-b]pyridazine-6,9-diamine
CFAMM00355311 CHEMBL140520 Bioactive SureCN7971416

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27160 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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