CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM436
Family Name Deoxycytidine kinase inhibitor N-[(1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-4-(1-benzothiophen-2-yl)pyridine-2-carboxamide family
No. of Seeds 2 No. of Other Members 5
Family Centroid CFAMM00311537 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase Chk1 and Cyclin-dependent kinase 7 Binder Superfamily
Class Class 3155

Cousin Family NamesSeedsMembers
Growth hormone receptor Ligand EP-51216 Family 34 390
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Histone deacetylase 1 Inhibitor N-hydroxy-5-(pyridin-3-yl)thio... 9 46
Endothelin B receptor Ligand IRL-2500 Family 34 87
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-[4... 4 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1231206 ... 6 7
5-hydroxytryptamine receptor 1A and D(3) dopamine receptor lig... 2 8
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Coagulation factor X and Prothrombin inhibitor (2S)-2-(benzyls... 4 4
Prostaglandin E2 receptor EP4 subtype ligand AGN-PC-09QJ7P family 2 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 13 37
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 2
Glycogen synthase kinase-3 beta inhibitor 7-(6-chloropyridin-2... 2 3
Neuronal acetylcholine receptor subunit alpha-7 ligand AGN-PC-... 7 1
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Cathepsin K and Cathepsin L1 inhibitor (2R)-N-(cyanomethyl)-4-... 2 1
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Serine/threonine-protein kinase Chk1 and Cyclin-dependent kina... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00311530 CHEMBL2346684 Bioactive 2-(1-benzothiophen-2-yl)-2-(2-fluoroanilino)-1-(2-pyridin-2-ylpyrrolidin-1-yl)ethanone
CFAMM00311537 CHEMBL1080444 Bioactive N-[(1S,3S)-3-(4-amino-5-fluoro-2-oxopyrimidin-1-yl)cyclopentyl]-4-(1-benzothiophen-2-yl)pyridine-2-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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