CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4368
Family Name D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide family
No. of Seeds 6 No. of Other Members 22
Family Centroid CFAMM00355455 Functional Category Bioactive
Superfamily P2X purinoceptor 7 and D(2) dopamine receptor Binder Superfamily 2
Class Class 3226

Cousin Family NamesSeedsMembers
Mitogen-activated protein kinase 12 Inhibitor ARRY-797 Family 13 41
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Coagulation factor X Inhibitor Apixaban Family 34 52
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
DCC-2036 family 2 5
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Bifunctional epoxide hydrolase 2 Inhibitor N-benzyl-6-(3,3,3-t... 21 62
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 31
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Neutrophil elastase inhibitor phenyl N-[(2S)-1-[(2S)-2-[[(3S)-... 2 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 28
5-hydroxytryptamine receptor 2A and Potassium voltage-gated ch... 5 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 3 4
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Translocator protein inhibitor 2-fluoro-N-[(2-methoxyphenyl)me... 8 27
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Cystic fibrosis transmembrane conductance regulator inhibitor ... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 3 0
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 0
Coagulation factor X inhibitor SureCN6785555 family 7 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-(cy... 3 2
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 1 1
Motilin receptor ligand SureCN2768193 family 2 1
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... 4 0
Orexin receptor type 2 and Orexin receptor type 1 ligand [(2R,... 4 0
Acetyl-CoA carboxylase 2 and Acetyl-CoA carboxylase 1 inhibito... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 7-met... 2 1
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 2 1
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Poly [ADP-ribose] polymerase 1 inhibitor 1-(4-methoxyphenyl)-3... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Adenosine receptor A3 and Adenosine receptor A1 ligand N-[2-(4... 3 2
Coagulation factor X inhibitor AGN-PC-046RMQ family 1 0
Vascular endothelial growth factor receptor 2 and Vascular end... 2 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 2
Coagulation factor X inhibitor AGN-PC-077MYE family 16 0
Coagulation factor X inhibitor SureCN5644036 family 30 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 6 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
B2 bradykinin receptor and Cytochrome P450 3A4 ligand SureCN15... 4 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Diacylglycerol O-acyltransferase 1 inhibitor AGN-PC-07ZCRO family 1 2
Neuromedin-K receptor ligand [3-(4-chlorophenyl)-1H-pyrazol-5-... 3 3
Glucagon receptor ligand AGN-PC-0DAGZC family 3 12
Dual specificity mitogen-activated protein kinase kinase 1 inh... 8 7
Cyclin-dependent kinase 2 inhibitor N-[(4-chlorophenyl)carbamo... 3 0
Dual specificity mitogen-activated protein kinase kinase 1 inh... 2 5
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355432 CHEMBL344677 Bioactive AGN-PC-075OSN
CFAMM00355457 CHEMBL142020 Bioactive N-[4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl]pyrazolo[1,5-a]pyridine-2-carboxamide
CFAMM00355455 CHEMBL140612 Bioactive N-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl]pyrazolo[1,5-a]pyridine-3-carboxamide
CFAMM00355453 CHEMBL141845 Bioactive N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]pyrazolo[1,5-a]pyridine-3-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26830 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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