CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM43717
Family Name Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activator 1 inhibitor AGN-PC-0BS4CG family
No. of Seeds 2 No. of Other Members 110
Family Centroid CFAMM00522199 Functional Category Bioactive with Natural Product
Superfamily Leukotriene B4 receptor 1 Ligand SC-51146 Superfamily
Class Class 544

Cousin Family NamesSeedsMembers
Alpha-1 adrenergic receptor ligand arylethanolamine derivative... 4 37
Muscarinic acetylcholine receptor Ligand Flavoxate Family 9 350
Insulin receptor Ligand Meglitinides Family 9 25
Ipriflavone family 62 2480
Agrimophol family 10 22
Cyclin-dependent kinase 2 Inhibitor Flavopiridol Family 4 124
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
C-C chemokine receptor type 5 Ligand GW873140 Family 6 78
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
Plasmepsin-2 Inhibitor PS-662477 Family 7 55
Leukotriene B4 receptor 1 Ligand SC-51146 Family 6 315
Acetylcholinesterase and Cholinesterase Inhibitor 3-[7-(benzyl... 22 303
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Vascular endothelial growth factor receptor 1 Ligand C[homophe... 1 66
Beta-2 adrenergic receptor Ligand Gnf-pf-1694 Family 4 70
Protein kinase C gamma type and Protein kinase C alpha type In... 2 1
Beta-2 adrenergic receptor and Beta-1 adrenergic receptor liga... 2 18
D(2) dopamine receptor ligand (E)-2,3-dihydroxybut-2-enedioic ... 6 10
Mu-type opioid receptor ligand 3-[(3R,4R)-1-[(2,4-dimethoxyphe... 2 4
D(4) dopamine receptor and D(3) dopamine receptor ligand 3-ben... 5 334
Peroxisome proliferator-activated receptor gamma ligand (9aS)-... 4 44
Melanin-concentrating hormone receptor 1 and Potassium voltage... 12 53
Potassium voltage-gated channel subfamily H member 2 and Melan... 5 4
C-C chemokine receptor type 1 and Chemokine (C-C motif) recept... 1 16
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 11
C-C chemokine receptor type 3 ligand N-[(3R)-1-[(6-fluoronapht... 1 4
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 4 3
Breast cancer type 1 susceptibility protein and Huntingtin inh... 1 7
Cathepsin D inhibitor (E)-N-butyl-4-[1-(3,4,5-trimethoxybenzoy... 1 3
Estrogen receptor ligand AGN-PC-073KIM family 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor (2Z)-... 2 10
Cyclin-dependent kinase 1 inhibitor AGN-PC-077KSM family 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 1 11
Putative NP ZINC02127056 Family 4 1
Putative NP ZINC08790868 Family 10 0
NP 2-((5-hydroxy-2,2-dimethyl-4-oxochroman-7-yl)oxy)-n-(3-meth... 18 0
NP 2-((1'-acetyl-4-oxospiro[chroman-2,4'-piperidin]-7-yl)oxy)-... 5 0
NP 1,3,8-trihydroxy-6-methyl-2-(morpholinomethyl)anthracene-9,... 2 0
4-methyl-7-[(4-methylpiperazin-1-ium-1-yl)methyl]-3-oxo-1-benz... 14 0
1-benzofuran-3-one NP ZINC02445091 Family 23 0
Putative NP ZINC20357755 Family 11 0
6-hydroxy-7-(morpholin-4-ylmethyl)-1-benzofuran-3-one NP ZINC2... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00522199 CHEMBL2029621 Bioactive AGN-PC-0BS4CG
CFAMM00522200 CHEMBL2029622 Bioactive 5,7-dihydroxy-8-[(1R)-1-(methylamino)hexyl]-2-phenylchromen-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24530 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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