CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM43936
Family Name E3 ubiquitin-protein ligase Mdm2 inhibitor SureCN5171589 family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00522751 Functional Category Bioactive
Superfamily E3 ubiquitin-protein ligase Mdm2 and NS5B protein Binder Superfamily
Class Class 702

Cousin Family NamesSeedsMembers
Glycine receptor subunit beta Ligand Gw 468816 Family 4 67
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Phospholipase D1 Inhibitor Halopemide Family 17 111
D(2) dopamine receptor Ligand PD-168077 Family 6 5
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Coagulation factor X inhibitor 3-amino-4-chloro-N-[(1R)-2-[4-(... 1 1
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 24 11
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1


External ID

Functional Category

Molecule Name

CFAMM00522754 CHEMBL207332 Bioactive 5-[(3S)-4-[1-(2-amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid
CFAMM00522753 CHEMBL207255 Bioactive 3-[[(2S)-2-(4-chlorophenyl)-2-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetyl]amino]propanoic acid
CFAMM00522759 CHEMBL379293 Bioactive 5-[(3S)-3-(4-chlorophenyl)-4-[1-(4-chlorophenyl)ethyl]-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid
CFAMM00522752 CHEMBL377614 Bioactive 5-[(3S)-4-[(1R)-1-(2-amino-4-chlorophenyl)ethyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid
CFAMM00522758 CHEMBL208554 Bioactive 5-[(3S)-4-[(2-amino-4-chlorophenyl)methyl]-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-3H-1,4-benzodiazepin-1-yl]pentanoic acid
CFAMM00522751 CHEMBL210151 Bioactive SureCN5171589
CFAMM00522757 CHEMBL383727 Bioactive SureCN5170564
CFAMM00522750 CHEMBL380214 Bioactive TDP-521252
CFAMM00522756 CHEMBL209169 Bioactive AGN-PC-03JLH4
CFAMM00522755 CHEMBL426321 Bioactive 5-[[(2S)-2-(4-chlorophenyl)-2-[(3S)-3-(4-chlorophenyl)-7-iodo-2,5-dioxo-1,3-dihydro-1,4-benzodiazepin-4-yl]acetyl]amino]pentanoic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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