CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM44101
Family Name Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-sulfanylethyl)benzoic acid family
No. of Seeds 2 No. of Other Members 3
Family Centroid CFAMM00523171 Functional Category Bioactive
Superfamily Glutamate carboxypeptidase 2 inhibitor 2-phenylmethoxy-6-(2-sulfanylethyl)benzoic acid Superfamily
Class Class 3483

Cousin Family NamesSeedsMembers
Retinoic acid receptor Ligand naphthoic acid derivative Adapal... 2 264
Prostaglandin G/H synthase 2 Inhibitor Diflunisal Family 7 421
Cyclooxygenase Inhibitor Fenoprofen Family 4 1077
Prostaglandin G/H synthase 1 Inhibitor Salicyclic Acid Family 3 39
Cyclooxygenase inhibitor salicylate derivative Aspirin family 3 234
Prostaglandin G/H synthase 2 Inhibitor Nabumetone Family 4 267
Signal transducer and activator of transcription 3 Inhibitor A... 5 249
Vitamin K epoxide reductase complex subunit 1 Inhibitor Warfar... 9 508
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor Mycophenola... 4 353
Heat shock protein 90, putative Inhibitor Cromoglicate Family 14 2827
D-alanyl-D-alanine carboxypeptidase Inhibitor B-lactams Family 59 1364
Aldehyde oxidase Inhibitor Isovanillin Family 6 429
Ipriflavone family 62 2480
Rotenone family 16 107
Danthron family 11 141
Agrimophol family 10 22
Leukotriene B4 receptor 1 Ligand LY293111 Family 24 79
Sphingosine kinase 2 Inhibitor Phenoxodiol Family 24 682
Steryl-sulfatase Inhibitor Stx 64 Family 7 160
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 9 123
Multidrug resistance protein Inhibitor Curcumin I Family 19 278
Interleukin-1 beta Inhibitor Diacerein Family 3 77
Integrase Inhibitor L-708,906 Family 1 8
Phospholipase A2 Inhibitor P-anisic Acid Family 2 178
Peroxisome proliferator-activated receptor gamma Ligand (2s)-2... 10 126
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 Ligand... 4 26
Steryl-sulfatase Inhibitor Sulfamic Acid 2-nonyl-4-oxo-4h-chro... 4 68
Aromatase and DNA-dependent protein kinase catalytic subunit I... 6 19
Phospholipase A2 Inhibitor 3,9-dihydroxy-2,10-diprenylpterocap... 9 25
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 2 56
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 9 81
Oestrogen receptor and Estrogen receptor beta Ligand 3,8-dihyd... 20 57
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor Ellagi... 1 11
Cytosolic phospholipase A2 Inhibitor [6,3''']biflavone Family 5 5
MO15-related protein kinase Pfmrk Inhibitor WR-289012 Family 2 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand 3-ben... 4 74
Cannabinoid receptor 2 Ligand 2-(2-methoxybenzyl)-3h-benzo[f]c... 6 32
Indoleamine 2,3-dioxygenase 1 Inhibitor 2-hydroxygarvin A Family 2 2
Interleukin-8 Inhibitor 2-(2-(2-fluorophenoxy)phenyl)acetic Ac... 2 4
Amine oxidase [flavin-containing] B Inhibitor (s)(+)-7-fluoro-... 11 11
NAD(P)H dehydrogenase [quinone] 1 Inhibitor Ethyl Bis(4-hydrox... 5 7
NAD(P)H dehydrogenase [quinone] 1 Inhibitor 4-hydroxy-3-(2-nap... 12 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 Inhibitor 6-meth... 2 36
Amine oxidase [flavin-containing] B Inhibitor 3-(4-methoxyphen... 3 29
Amine oxidase [flavin-containing] B Inhibitor 4-oxo-4h-chromen... 2 3
Cytochrome P450 3A4 Inhibitor Diethoxyflourescein Family 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 Ligand 2-(3-c... 5 72
Epidermal growth factor receptor Ligand 3-(3-chloro-phenyl)-5,... 10 64
Protein farnesyltransferase subunit beta Inhibitor Cylindrol A... 3 43
Prostaglandin G/H synthase 2 Inhibitor 3,4-dibenzyloxy-2'-hydr... 7 40
Androgen receptor Ligand Palodesangren E Family 12 43
CGMP-dependent protein kinase Inhibitor Tenellone A Family 1 7
Liver carboxylesterase 1 Inhibitor 2-methoxy-3,4-methylenediox... 4 26
ELAV-like protein 1 and Myosin light chain kinase, smooth musc... 1 32
Retinoic acid receptor RXR-alpha and Peroxisome proliferator-a... 3 17
Arachidonate 5-lipoxygenase inhibitor 7-[[3-fluoro-5-(3-hydrox... 2 10
Peroxisome proliferator-activated receptor delta ligand SureCN... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 7 13
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 7
Protein kinase C beta type and Protein kinase C eta type inhib... 1 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 7
Estrogen receptor beta and Estrogen receptor ligand (5-hydroxy... 1 1
Peroxisome proliferator-activated receptor alpha and Peroxisom... 2 8
Corticosteroid 11-beta-dehydrogenase isozyme 2 and Corticoster... 1 2
Benzofurans Metabolite 4-Hydroxyphthalide Family 1 1
Putative NP ZINC31165975 Family 4 0
NP 6-(4-ethoxyphenyl)-1,3-dimethyl-4-oxo-4h-cyclohepta[c]furan... 13 3
(6-bromo-5,8-dioxonaphthalen-1-yl) acetate NP 6-bromo-5,8-diox... 1 1
2-(2,5-dimethoxyphenyl)sulfonyl-3,6-dimethoxybenzoate NP ZINC0... 1 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00523173 CHEMBL2152564 Bioactive 2-[(2-carboxyphenyl)methoxy]-6-(2-sulfanylethyl)benzoic acid
CFAMM00523171 CHEMBL2152563 Bioactive 2-phenylmethoxy-6-(2-sulfanylethyl)benzoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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