CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM44156
Family Name Probable G-protein coupled receptor 142 ligand (2S)-2-[[(2R)-oxolan-2-yl]methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00523276 Functional Category Bioactive
Superfamily DNA polymerase beta and Muscleblind-like protein 1 Binder Superfamily 3
Class Class 3038

Cousin Family NamesSeedsMembers
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
HIV-1 protease Inhibitor Atazanavir Family 16 58
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
FK506-binding protein 1A Inhibitor Gpi-1046 Family 4 10
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin K and Cathepsin S Inhibitor P2,p3 Ketoamide Derivati... 2 1
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Stromelysin-1 and 72 kDa type IV collagenase inhibitor (2S,4R)... 2 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 2 3
Thromboxane A2 receptor ligand SureCN8058805 family 2 1


External ID

Functional Category

Molecule Name

CFAMM00523276 CHEMBL2164843 Bioactive (2S)-2-[[(2R)-oxolan-2-yl]methylamino]-N-(2-oxo-5-pyridin-4-yl-1H-pyridin-3-yl)-3-phenylpropanamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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Computer-aided Drug Design
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