CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4429
Family Name Acetylcholinesterase inhibitor 2-[2-(1-benzylpiperidin-4-yl)ethyl]-4-nitroisoindole-1,3-dione family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00355971 Functional Category Bioactive
Superfamily Angiotensin-converting enzyme Inhibitor [cyclopentyl-(2-nitro-benzoyl)-amino]-acetic Acid Superfamily
Class Class 2203

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Tumor necrosis factor Inhibitor Thalidomide Family 3 50
Serum albumin Inhibitor Ebselen Family 3 62
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Amonafide family 3 35
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Vasopressin-neurophysin 2-copeptin Inhibitor Niravoline Family 7 45
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Liver carboxylesterase 1 Inhibitor 1-methyl-1h-indole-2,3-dion... 10 35
Epidermal growth factor receptor Ligand 5,6-bis-p-tolylamino-i... 2 2
MO15-related protein kinase Pfmrk Inhibitor 5-nitro-1h-indole-... 1 4
Poly [ADP-ribose] polymerase 1 Inhibitor 8-amino-6h,11h-indeno... 3 9
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Oxysterols receptor LXR-alpha Ligand 2-(2-phenethylphenyl)isoi... 4 7
Cannabinoid receptor 2 Ligand N1-(4-bromophenyl)-n2,n2-dipenty... 4 21
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor N-(4-(... 2 17
Sodium-dependent dopamine transporter and Sodium-dependent nor... 2 7
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 2 4
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Cholecystokinin receptor type A Ligand VL-0494 Family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 53 289
D(4) dopamine receptor ligand AGN-PC-074VC9 family 2 3
Acetylcholinesterase inhibitor AGN-PC-07ZFTY family 1 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 4 5
Sigma non-opioid intracellular receptor 1 ligand 2-(2-nitrophe... 2 5
D(2) dopamine receptor and D(3) dopamine receptor ligand 1,1-d... 2 7
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 5 1
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 2 11
5-hydroxytryptamine receptor 1A and Alpha-1B adrenergic recept... 3 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[5-... 3 0
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Sigma non-opioid intracellular receptor 1 and 5-hydroxytryptam... 1 0
Kappa-type opioid receptor ligand N-[(2S)-1-(2,5-dihydropyrrol... 1 1
Histone deacetylase 1 inhibitor AGN-PC-07ZGOT family 2 1
Caspase-3 inhibitor Benzamide, 3-nitro-N-(1,2,3,4-tetrahydro-1... 2 3
Beta-lactamase inhibitor CHEMBL1406823 family 1 1
(8aS,11aR)-10-ethyl-8-(4-nitrobenzoyl)-11a,11b-dihydro-8H-pyrr... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355971 CHEMBL141001 Bioactive 2-[2-(1-benzylpiperidin-4-yl)ethyl]-4-nitroisoindole-1,3-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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