CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM4432
Family Name Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibitor AC1NS8OJ family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00355981 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR and Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Binder Superfamily 2
Class Class 850

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Tyrosine-protein kinase JAK2 Inhibitor TG101348 Family 2 4
AP26113 family 16 90
SB1518 family 7 103
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 10
Proto-oncogene tyrosine-protein kinase Src Inhibitor PD166285 ... 6 70
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Peptidyl-prolyl cis-trans isomerase A Inhibitor 3-[3-(3-benzyl... 3 34
Platelet-derived growth factor receptor alpha and Fibroblast g... 3 47
Hepatocyte growth factor receptor Ligand BMS-777607 Family 10 1
Mitogen-activated protein kinase 14 Inhibitor Pamapimod Family 15 7
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 1 inhibi... 2 22
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2J2 inhib... 1 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 8 1
Mitogen-activated protein kinase 14 inhibitor N-(4-aminobutyl)... 1 28
Hepatocyte growth factor receptor ligand SureCN4492034 family 2 2
Inositol monophosphatase 1 inhibitor CHEMBL1588383 family 1 6
Vascular endothelial growth factor receptor 2 ligand 1-[4-[6-a... 11 13
Glycogen synthase kinase-3 beta inhibitor 6-[(2S)-2-(2-methoxy... 1 0
Metabotropic glutamate receptor 1 and Metabotropic glutamate r... 11 7
Corticotropin-releasing factor receptor 1 ligand AGN-PC-009TSL... 3 3
Wee1-like protein kinase and ALK tyrosine kinase receptor liga... 1 9
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Epidermal growth factor receptor ligand N-[3-[7-[2-methoxy-4-(... 9 3
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762WF family 2 0
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 6 13
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 1 1
Lysine--tRNA ligase and Tyrosine-protein kinase Lyn inhibitor ... 1 0
Tyrosine-protein kinase ABL1 and Breakpoint cluster region pro... 8 5
Dihydrofolate reductase inhibitor AC1LAPW3 family 3 0
Tyrosine-protein kinase Lck inhibitor SureCN374434 family 1 1
Tyrosine-protein kinase Lck and Mitogen-activated protein kina... 2 0
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 3
Acyl-CoA desaturase inhibitor SureCN1182546 family 2 5
Cyclin-dependent kinase 4 and Cyclin-dependent kinase 2 inhibi... 1 4
Vascular endothelial growth factor receptor 2 ligand SureCN472... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00355981 CHEMBL141018 Bioactive AC1NS8OJ

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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